PT  - JOURNAL ARTICLE
AU  - T Yamakami
AU  - O Taguchi
AU  - EC Gabazza
AU  - M Yoshida
AU  - T Kobayashi
AU  - H Kobayashi
AU  - H Yasui
AU  - H Ibata
AU  - Y Adachi
TI  - Arterial endothelin-1 level in pulmonary emphysema and interstitial lung disease. Relation with pulmonary hypertension during exercise
AID  - 10.1183/09031936.97.10092055
DP  - 1997 Sep 01
TA  - European Respiratory Journal
PG  - 2055--2060
VI  - 10
IP  - 9
4099  - http://erj.ersjournals.com/content/10/9/2055.short
4100  - http://erj.ersjournals.com/content/10/9/2055.full
SO  - Eur Respir J1997 Sep 01; 10
AB  - This study was undertaken to assess the arterial plasma levels of endothelin-1 (ET-1) and their relationship with pulmonary haemodynamic and gas exchange variables during exercise in patients with emphysema and interstitial lung disease (ILD). Incremental cycle ergometry was performed in all patients up to maximal capacity. At rest, arterial ET-1 levels were higher in emphysema (1.86 +/- 0.35 pg.mL-1; p &amp;lt; 0.02) and ILD (1.75 +/- 0.25 pg.mL-1; p &amp;lt; 0.03) patients than in controls (1.35 +/- 0.18 pg.mL-1). Emphysema (2.08 +/- 0.26 versus 1.70 +/- 0.40 pg.mL-1) and ILD (1.98 +/- 0.21 versus 1.67 +/- 0.02 pg.mL-1) patients with pulmonary hypertension (PH) presented significantly (p &amp;lt; 0.05) higher arterial ET-1 levels than those without. At rest, arterial ET-1 levels were significantly correlated with mean pulmonary arterial pressure (Ppa) in both ILD (r = 0.8, p = 0.01) and emphysema (r = 0.5, p = 0.03) patients. During exercise, the arterial ET-1 levels were significantly correlated with arterial oxygen (Pa,O2) (r = -0.6, p = 0.04), alveolar-arterial oxygen difference (r = 0.8, p = 0.01), and Ppa (r = 0.6, p = 0.04) in ILD patients, but not in those with emphysema. In brief, the results of this study suggest that arterial endothelin-1 is markedly increased in interstitial lung disease and emphysema patients, and that, it is related to the exercise-induced exacerbation of pulmonary hypertension in patients with interstitial lung disease, but not in those with emphysema.