RT Journal Article
SR Electronic
T1 Distribution of inhaled fluticasone propionate between human lung tissue and serum in vivo
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1496
OP 1499
DO 10.1183/09031936.97.10071496
VO 10
IS 7
A1 N Esmailpour
A1 P Hogger
A1 KF Rabe
A1 U Heitmann
A1 M Nakashima
A1 P Rohdewald
YR 1997
UL http://erj.ersjournals.com/content/10/7/1496.abstract
AB High retention of inhaled glucocorticoids in the airways means prolonged anti-inflammatory action and low delivery into the serum. The objective of this study was to investigate the retention in and distribution of inhaled fluticasone propionate (FP) between central and peripheral human lung tissue and serum in vivo. In 17 patients undergoing lung resection surgery, a single 1.0 mg dose of FP was inhaled at varying time-points (range 2.8-21.7 h) preoperatively. Peripheral and central lung tissue was obtained, and blood was drawn simultaneously. FP concentrations in central lung tissue were approximately three to four times higher than peripheral lung tissue concentrations, which in turn, exceeded those found in serum by 10 times. FP was detectable up to 21 and 16 h, respectively, after inhalation, with drug levels falling almost in parallel in peripheral lung tissue and in serum. The results of this study demonstrate that fluticasone propionate is retained in lung tissue for a long time. Serum concentrations after a single inhaled dose are low. Retention of high concentrations of fluticasone propionate in the airways may promote high topical anti-inflammatory activity.