PT  - JOURNAL ARTICLE
AU  - G Persson
AU  - B Olsson
AU  - S Soliman
TI  - The impact of inspiratory effort on inspiratory flow through Turbuhaler in asthmatic patients
AID  - 10.1183/09031936.97.10030681
DP  - 1997 Mar 01
TA  - European Respiratory Journal
PG  - 681--684
VI  - 10
IP  - 3
4099  - http://erj.ersjournals.com/content/10/3/681.short
4100  - http://erj.ersjournals.com/content/10/3/681.full
SO  - Eur Respir J1997 Mar 01; 10
AB  - To investigate the impact of the inhalation effort on the peak inspiratory flow through Turbuhaler, 100 asthmatics having a wide range of asthma severity (baseline forced expiratory volume in one second 28-127% of predicted normal) were studied. Each patient inhaled through four modifications of empty Turbuhaler inhalers, using first a "deep" inhalation and then a "forceful and deep" inhalation manoeuvre. Peak inspiratory flow increased by an average of 20% using a "forceful and deep" as compared to a "deep" inhalation, with a markedly higher increase for the patients who had a low peak inspiratory flow using the deep inhalation. Virtually all patients (97-100%) attained a peak inspiratory flow > or = 40 L x min(-1) after a "forceful and deep" inhalation. This study demonstrates that instructing the patient to take a "forceful and deep" inhalation optimizes the use of Turbuhaler. Irrespective of asthma severity, the vast majority of patients could attain a sufficiently high peak inspiratory flow with a "forceful and deep" inhalation.