PT  - JOURNAL ARTICLE
AU  - Y. Tsuchiya
AU  - N. Takayanagi
AU  - H. Sugiura
AU  - Y. Miyahara
AU  - D. Tokunaga
AU  - Y. Kawabata
AU  - Y. Sugita
TI  - Lung diseases directly associated with rheumatoid arthritis and their relationship to outcome
AID  - 10.1183/09031936.00019210
DP  - 2011 Jun 01
TA  - European Respiratory Journal
PG  - 1411--1417
VI  - 37
IP  - 6
4099  - http://erj.ersjournals.com/content/37/6/1411.short
4100  - http://erj.ersjournals.com/content/37/6/1411.full
SO  - Eur Respir J2011 Jun 01; 37
AB  - The outcome and cause of death of each lung disease directly associated with rheumatoid arthritis (RA-LD) have been poorly investigated. A retrospective study was conducted of 144 patients with RA-LD, in whom the median follow-up period after the initial visit for a respiratory examination was 4.5 yrs. A total of 57 patients were identified with usual interstitial pneumonia (UIP), 31 with bronchiectasis, 16 with nonspecific interstitial pneumonia (NSIP), 11 with bronchiolitis, five with organising pneumonia (OP), five with diffuse alveolar damage (DAD) and 19 with combined disease. The 5-yr survival rates were 36.6% in the UIP group, 87.1% in the bronchiectasis group, 93.8% in the NSIP group, 88.9% in the bronchiolitis group, 60.0% in the OP group and 20.0% in the DAD group. Survival of patients with DAD was worse than that of patients with UIP. Overall, survival of patients with UIP was worse than that of patients with bronchiectasis, NSIP or bronchiolitis. Of the 144 patients, 71 (49.3%) died, of whom 58 (81.7%) died due to respiratory lesions. Of patients with RA-LD, patients with DAD experienced the highest mortality, and the survival of patients with UIP was worse than that of patients with NSIP.