RT Journal Article
SR Electronic
T1 Prediction of metabolic and cardiopulmonary responses to maximum cycle ergometry: a randomised study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1304
OP 1313
DO 10.1183/09031936.99.14613049
VO 14
IS 6
A1 JA Neder
A1 LE Nery
A1 A Castelo
A1 S Andreoni
A1 MC Lerario
A1 A Sachs
A1 AC Silva
A1 BJ Whipp
YR 1999
UL http://erj.ersjournals.com/content/14/6/1304.abstract
AB All of the most widely-cited studies for the prediction of maximum exercise responses have utilized either volunteers or referred subjects. Therefore, selection bias, with overestimation of the reference values, is a likely consequence. In order to establish a set of predictive equations for the gas exchange, ventilatory and cardiovascular responses to maximum ramp-incremental cycle ergometry, this study prospectively evaluated 120 sedentary individuals (60 males, 60 females, aged 20-80), randomly-selected from >8,000 subjects. Regular physical activity pattern by questionnaire, body composition by anthropometry and dual energy X-ray absorptiometry (n = 75) and knee strength by isokinetic dynamometry were also assessed. Previously reported equations typically overestimated the subjects' peak oxygen uptake (p<0.05). Prediction linear equations for the main variables of clinical interest were established by backward stepwise regression analysis including: sex, age, knee extensor peak torque, bone-free lean leg mass, total and lean body mass, height, and physical activity scores. Reference intervals (95% confidence limits) were calculated: some of these values differed markedly from those formerly recommended. The results therefore might provide a more appropriate frame of reference for interpretation of the responses to symptom-limited ramp incremental cycle ergometry in sedentary subjects; i.e. those usually referred for clinical cardiopulmonary exercise tests.