TY - JOUR T1 - Ventilation variability inversely correlates to ejection fraction in heart failure JF - European Respiratory Journal JO - Eur Respir J SP - 1482 LP - 1483 DO - 10.1183/09031936.00044910 VL - 36 IS - 6 AU - R.R.T. Castro AU - L.M. Antunes-Correa AU - L.M. Ueno AU - M.U.P.B. Rondon AU - C.E. Negrão AU - A.C.L. Nobrega Y1 - 2010/12/01 UR - http://erj.ersjournals.com/content/36/6/1482.abstract N2 - To the Editors:Heart failure is currently considered a systemic disease. In this context, there is growing interest in cardiopulmonary interactions during rest, sleep and exercise 1. Periodic breathing during exercise is characterised by regular waxing and waning of minute ventilation (V’E) due to oscillations in central respiratory drive. Periodic breathing independently predicts mortality in heart failure patients 2, but is not directly correlated with low left ventricular ejection fraction. For example, the occurrence of periodic breathing could predict cardiac mortality in patients who were waiting for cardiac transplantation, independent of ejection fraction 2.Clinical experience shows that some heart failure … ER -