PT  - JOURNAL ARTICLE
AU  - H Suzuki
AU  - S Goto
AU  - K Ikeda
AU  - T Oshima
AU  - M Furukawa
AU  - T Takasaka
TI  - IL-12 receptor beta2 and CD30 expression in paranasal sinus mucosa of patients with chronic sinusitis
AID  - 10.1034/j.1399-3003.1999.13e13.x
DP  - 1999 May 01
TA  - European Respiratory Journal
PG  - 1008--1013
VI  - 13
IP  - 5
4099  - http://erj.ersjournals.com/content/13/5/1008.short
4100  - http://erj.ersjournals.com/content/13/5/1008.full
SO  - Eur Respir J1999 May 01; 13
AB  - The aetiology of chronic sinusitis is still poorly understood. The expression of T-helper 1 (Th1) and T-helper 2 (Th2) cell markers, interleukin (IL)-12 receptor beta2 subunit (IL-12Rbeta2) messenger ribonucleic acid (mRNA) and CD30, respectively, were investigated in the paranasal sinus mucosa of patients with chronic sinusitis in an attempt to elucidate the involvement of Th1 and Th2 cells in this disease. Anterior ethmoidal mucosae were surgically obtained from two groups of patients with chronic sinusitis: those who had allergic rhinitis (allergic group, n=11) and those without allergy (nonallergic group, n=11). IL-12Rbeta2 mRNA was quantified by means of the reverse transcription polymerase chain reaction, and CD30-positive cells were examined immunohistochemically. Both IL-12Rbeta2 mRNA and CD30 were expressed in the sinus mucosa of the allergic and nonallergic groups. The proportion of mononuclear cells which were CD30-positive in the sinus mucosa was significantly greater in the allergic than in the nonallergic group. The expression levels of IL-12Rbeta2 mRNA were virtually equivalent in both groups. These results suggest a T-helper 2-dominated mucosal reaction in the allergic compared to the nonallergic group, and indicate T-helper 1 activity in the sinus mucosa of both groups. The ubiquity of T-helper 1 cells suggests that they play a role in maintaining local mucosal defences against foreign antigens, which continually enter the upper respiratory tract.