RT Journal Article SR Electronic T1 Uptake and 4-week quit rates from an opt-out co-located smoking cessation service delivered alongside community-based low-dose computed tomography screening within the Yorkshire Lung Screening Trial JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 2301768 DO 10.1183/13993003.01768-2023 VO 63 IS 4 A1 Murray, Rachael L. A1 Alexandris, Panos A1 Baldwin, David A1 Brain, Kate A1 Britton, John A1 Crosbie, Philip A.J. A1 Gabe, Rhian A1 Lewis, Sarah A1 Parrott, Steve A1 Quaife, Samantha L. A1 Tam, Hui Zhen A1 Wu, Qi A1 Beeken, Rebecca A1 Copeland, Harriet A1 Eckert, Claire A1 Hancock, Neil A1 Lindop, Jason A1 McCutchan, Grace A1 Marshall, Catriona A1 Neal, Richard D. A1 Rogerson, Suzanne A1 Quinn Scoggins, Harriet D. A1 Simmonds, Irene A1 Thorley, Rebecca A1 Callister, Matthew E. YR 2024 UL https://publications.ersnet.org//content/63/4/2301768.abstract AB Background Up to 50% of those attending for low-dose computed tomography screening for lung cancer continue to smoke and co-delivery of smoking cessation services alongside screening may maximise clinical benefit. Here we present data from an opt-out co-located smoking cessation service delivered alongside the Yorkshire Lung Screening Trial (YLST).Methods Eligible YLST participants were offered an immediate consultation with a smoking cessation practitioner (SCP) at their screening visit with ongoing smoking cessation support over subsequent weeks.Results Of 2150 eligible participants, 1905 (89%) accepted the offer of an SCP consultation during their initial visit, with 1609 (75%) receiving ongoing smoking cessation support over subsequent weeks. Uptake of ongoing support was not associated with age, ethnicity, deprivation or educational level in multivariable analyses, although men were less likely to engage (adjusted OR (ORadj) 0.71, 95% CI 0.56–0.89). Uptake was higher in those with higher nicotine dependency, motivation to stop smoking and self-efficacy for quitting. Overall, 323 participants self-reported quitting at 4 weeks (15.0% of the eligible population); 266 were validated by exhaled carbon monoxide (12.4%). Multivariable analyses of eligible smokers suggested 4-week quitting was more likely in men (ORadj 1.43, 95% CI 1.11–1.84), those with higher motivation to quit and previous quit attempts, while those with a stronger smoking habit in terms of cigarettes per day were less likely to quit.Conclusions There was high uptake for co-located opt-out smoking cessation support across a wide range of participant demographics. Protected funding for integrated smoking cessation services should be considered to maximise programme equity and benefit.Uptake of stop smoking support co-located within a lung cancer screening programme was high across a range of participant demographics and quit rates were in excess of those reported in other studies at similar time-points without such intervention. https://bit.ly/3vc8bln