RT Journal Article
SR Electronic
T1 Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2300925
DO 10.1183/13993003.00925-2023
VO 62
IS 5
A1 Global Tuberculosis Network and TB/COVID-19 Global Study Group
A1 Casco, Nicolas
A1 Jorge, Alberto Levi
A1 Palmero, Domingo Juan
A1 Alffenaar, Jan-Willem
A1 Fox, Greg J.
A1 Ezz, Wafaa
A1 Cho, Jin-Gun
A1 Denholm, Justin
A1 Skrahina, Alena
A1 Solodovnikova, Varvara
A1 Arbex, Marcos Abdo
A1 Alves, Tatiana
A1 Rabahi, Marcelo Fouad
A1 Pereira, Giovana Rodrigues
A1 Sales, Roberta
A1 Silva, Denise Rossato
A1 Saffie, Muntasir M.
A1 Salinas, Nadia Escobar
A1 Miranda, Ruth Caamaño
A1 Cisterna, Catalina
A1 Concha, Clorinda
A1 Fernandez, Israel
A1 Villalón, Claudia
A1 Vera, Carolina Guajardo
A1 Tapia, Patricia Gallegos
A1 Cancino, Viviana
A1 Carbonell, Monica
A1 Cruz, Arturo
A1 Muñoz, Eduardo
A1 Muñoz, Camila
A1 Navarro, Indira
A1 Pizarro, Rolando
A1 Cristina Sánchez, Gloria Pereira
A1 Vergara Riquelme, Maria Soledad
A1 Vilca, Evelyn
A1 Soto, Aline
A1 Flores, Ximena
A1 Garavagno, Ana
A1 Bahamondes, Martina Hartwig
A1 Merino, Luis Moyano
A1 Pradenas, Ana María
A1 Revillot, Macarena Espinoza
A1 Rodriguez, Patricia
A1 Salinas, Angeles Serrano
A1 Taiba, Carolina
A1 Valdés, Joaquín Farías
A1 Subiabre, Jorge Navarro
A1 Ortega, Carlos
A1 Palma, Sofia
A1 Castillo, Patricia Perez
A1 Pinto, Mónica
A1 Bidegain, Francisco Rivas
A1 Venegas, Margarita
A1 Yucra, Edith
A1 Li, Yang
A1 Cruz, Andres
A1 Guelvez, Beatriz
A1 Victoria Plaza, Regina
A1 Tello Hoyos, Kelly Yoana
A1 Cardoso-Landivar, José
A1 Van Den Boom, Martin
A1 Andréjak, Claire
A1 Blanc, François-Xavier
A1 Dourmane, Samir
A1 Froissart, Antoine
A1 Izadifar, Armine
A1 Rivière, Frédéric
A1 Schlemmer, Frédéric
A1 Manika, Katerina
A1 Diallo, Boubacar Djelo
A1 Hassane-Harouna, Souleymane
A1 Artiles, Norma
A1 Mejia, Licenciada Andrea
A1 Gupta, Nitesh
A1 Ish, Pranav
A1 Mishra, Gyanshankar
A1 Patel, Jigneshkumar M.
A1 Singla, Rupak
A1 Udwadia, Zarir F.
A1 Alladio, Francesca
A1 Angeli, Fabio
A1 Calcagno, Andrea
A1 Centis, Rosella
A1 Codecasa, Luigi Ruffo
A1 De Lauretis, Angelo
A1 Esposito, Susanna M.R.
A1 Formenti, Beatrice
A1 Gaviraghi, Alberto
A1 Giacomet, Vania
A1 Goletti, Delia
A1 Gualano, Gina
A1 Matteelli, Alberto
A1 Migliori, Giovanni Battista
A1 Motta, Ilaria
A1 Palmieri, Fabrizio
A1 Pontali, Emanuele
A1 Prestileo, Tullio
A1 Riccardi, Niccolò
A1 Saderi, Laura
A1 Saporiti, Matteo
A1 Sotgiu, Giovanni
A1 Spanevello, Antonio
A1 Stochino, Claudia
A1 Tadolini, Marina
A1 Torre, Alessandro
A1 Villa, Simone
A1 Visca, Dina
A1 Kurhasani, Xhevat
A1 Furjani, Mohammed
A1 Rasheed, Najia
A1 Danila, Edvardas
A1 Diktanas, Saulius
A1 Ridaura, Ruy López
A1 Luna López, Fátima Leticia
A1 Torrico, Marcela Muñoz
A1 Rendon, Adrian
A1 Akkerman, Onno W.
A1 Chizaram, Onyeaghala
A1 Al-Abri, Seif
A1 Alyaquobi, Fatma
A1 Althohli, Khalsa
A1 Aguirre, Sarita
A1 Teixeira, Rosarito Coronel
A1 De Egea, Viviana
A1 Irala, Sandra
A1 Medina, Angélica
A1 Sequera, Guillermo
A1 Sosa, Natalia
A1 Vázquez, Fátima
A1 Llanos-Tejada, Félix K.
A1 Manga, Selene
A1 Villanueva-Villegas, Renzo
A1 Araujo, David
A1 Sales Marques, Raquel DuarteTânia
A1 Socaci, Adriana
A1 Barkanova, Olga
A1 Bogorodskaya, Maria
A1 Borisov, Sergey
A1 Mariandyshev, Andrei
A1 Kaluzhenina, Anna
A1 Vukicevic, Tatjana Adzic
A1 Stosic, Maja
A1 Beh, Darius
A1 Ng, Deborah
A1 Ong, Catherine W.M.
A1 Solovic, Ivan
A1 Dheda, Keertan
A1 Gina, Phindile
A1 Caminero, José A.
A1 De Souza Galvão, Maria Luiza
A1 Dominguez-Castellano, Angel
A1 García-García, José-María
A1 Pinargote, Israel Molina
A1 Fernandez, Sarai Quirós
A1 Sánchez-Montalvá, Adrián
A1 Huguet, Eva Tabernero
A1 Murguiondo, Miguel Zabaleta
A1 Bart, Pierre-Alexandre
A1 Mazza-Stalder, Jesica
A1 D'Ambrosio, Lia
A1 Kamolwat, Phalin
A1 Bakko, Freya
A1 Barnacle, James
A1 Bird, Sophie
A1 Brown, Annabel
A1 Chandran, Shruthi
A1 Killington, Kieran
A1 Man, Kathy
A1 Papineni, Padmasayee
A1 Ritchie, Flora
A1 Tiberi, Simon
A1 Utjesanovic, Natasa
A1 Zenner, Dominik
A1 Hearn, Jasie L.
A1 Heysell, Scott
A1 Young, Laura
YR 2023
UL https://publications.ersnet.org//content/62/5/2300925.abstract
AB Background Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19.Methods We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both.Results Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03–1.07), HIV infection (HR 2.29, 95% CI 1.02–5.16) and invasive ventilation (HR 4.28, 95% CI 2.34–7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02–1.04), male sex (HR 2.21, 95% CI 1.24–3.91), oxygen requirement (HR 7.93, 95% CI 3.44–18.26) and invasive ventilation (HR 2.19, 95% CI 1.36–3.53).Conclusions In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.In 778 TB/COVID-19 co-infected patients, 77% TB treatment success and 11% TB mortality was observed, with 71% recovering from COVID-19 and 13% COVID-19-associated mortality. Mortality was higher in those diagnosed with COVID-19 before/during TB treatment. https://bit.ly/3PQSw17