PT  - JOURNAL ARTICLE
AU  - Xu, Shanshan
AU  - Marcon, Alessandro
AU  - Bertelsen, Randi Jacobsen
AU  - Benediktsdottir, Bryndis
AU  - Gislason, Thorarinn
AU  - Brandt, Jørgen
AU  - Frohn, Lise Marie
AU  - Geels, Camilla
AU  - Heinrich, Joachim
AU  - Holm, Mathias
AU  - Janson, Christer
AU  - Jogi, Rain
AU  - Markevych, Iana
AU  - Orru, Hans
AU  - Oudin, Anna
AU  - Schlünssen, Vivi
AU  - Sigsgaard, Torben
AU  - Johannessen, Ane
TI  - Associations of long-term exposure to low-level air pollution and greenness with incidence of protracted cough: results from the RHINE study
AID  - 10.1183/13993003.congress-2023.PA1598
DP  - 2023 Sep 09
TA  - European Respiratory Journal
PG  - PA1598
VI  - 62
IP  - suppl 67
4099  - http://erj.ersjournals.com/content/62/suppl_67/PA1598.short
4100  - http://erj.ersjournals.com/content/62/suppl_67/PA1598.full
SO  - Eur Respir J2023 Sep 09; 62
AB  - Background: Few studies have examined exposure to air pollution and greenness over three decades and incidence of symptoms common in obstructive respiratory disease.Aim: We investigated incidence of protracted cough in relation to exposure to particulate matter (PM2.5 and PM10), black carbon (BC), nitrogen dioxide (NO2), ozone (O3) and greenness (normalized difference vegetation index (NDVI)).Methods: We analyzed outcome data from the fourth Respiratory Health in Northern Europe (RHINE IV) study in 2022 (n = 9910 participants aged 50-75 years) as related to modelled air pollution and greenness exposure from 1990, 2000 and 2010. We used Poisson regression model with log person-year at risk as the offset, adjusting for covariates in 2010 (age, sex, smoking status, pack-years smoking, body mass index, education and marital status).Results: We identified 624 incident cases of protracted cough during 13.0 years mean follow-up. The adjusted incidence rate ratios (IRR) (95% confidence interval (CI)) for protracted cough were 1.29 (1.05-1.57) and 1.23 (1.07-1.42) per 9.7 µg/m3 increase in PM2.5 and per 0.6 µg/m3 in BC, respectively in 1990 exposure. Similar associations were seen for PM10 and NO2, but not statistically significant. No association was seen for NDVI whereas O3 was inversely associated with protracted cough across all time points, the adjusted IRR was 0.80 (0.69-0.94) per 10.9 μg/m3 increase in O3 in 1990 exposure.Conclusion: Long-term exposure to low-level PM2.5 and BC increased risk for incident symptoms of protracted cough, while O3 had an inverse association. Living in green neighborhoods was not associated with cough in our study.FootnotesCite this article as: European Respiratory Journal 2023; 62: Suppl. 67, PA1598.This abstract was presented at the 2023 ERS International Congress, in session “Inflammatory endotyping: the macrophage across disease areas”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).