RT Journal Article
SR Electronic
T1 Preconception air pollution/greenness exposure and pregnancy outcomes:The Life-GAP Project
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA311
DO 10.1183/13993003.congress-2023.PA311
VO 62
IS suppl 67
A1 Sinsamala, Robin Mzati
A1 Marcon, Alessandro
A1 Bertelsen, Randi
A1 Janson, Christer
A1 Holm, Mathias
A1 Modig, Lars
A1 Gislason, Thorarinn
A1 Sigsgaard, Torben
A1 Orru, Hans
A1 Geels, Camilla
A1 Frohn, Lise Marie
A1 Brandt, Jørgen
A1 Gomez Real, Francisco
A1 Accordini, Simone
A1 Markevych, Iana
A1 Svanes, Cecilie
A1 Johannessen, Ane
YR 2023
UL https://publications.ersnet.org//content/62/suppl_67/PA311.abstract
AB Background: Birth weight (BW) and preterm birth (PTB) increase the risk of impaired lung function. Decreasing the risk of low BW and PTB may improve respiratory health.Aim: To investigate the association of maternal exposure to air pollution and greenness during pregnancy with BW and PTB.Methods: We analysed data on 5434 children from 2742 mothers within the Respiratory Health in Northern Europe (RHINE) study. Exposure to greenness (Normalized Difference Vegetation Index, NDVI), modelled particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), ozone (O3), and black carbon (BC) were estimated for mothers based on residential address at each pregnancy. We used two-level (level 1: offspring; level 2: mother) linear and logistic regression models, while adjusting for centre, maternal age, education, smoking, body silhouette, and comorbidity.Results: Median (interquartile range, IQR) NDVI300m was 0.3(0.2-0.4), for pollutants in µg/m3 was 9.5(7.1-13.0), 16.4(11.1-21.3), 15.8(8.9-21.6), 49.5(45.2-54.0), and 0.6(0.4-0.8) for PM2.5, PM10, NO2, O3 and BC respectively. An IQR increase in NDVI300m was associated with an increase in BW of 29g (95%CI: 13-44), 23% lower odds of low BW (<2500g) (OR=0.77, 95% CI:0.64-0.94), and 14% increased odds of high BW (>4000g) (OR=1.14, 95% CI:1.02-1.26). The association was consistent after adjusting for air pollutants’ exposures or using different NDVI buffers(100m and 500m). No association of greenness exposure with PTB were observed. Air pollution exposure was associated with neither BW nor PTB.Conclusion: Maternal long-term exposure to greenness has a positive association with BW. Greenness could contribute to healthier pregnancies and improve lung health.FootnotesCite this article as: European Respiratory Journal 2023; 62: Suppl. 67, PA311.This abstract was presented at the 2023 ERS International Congress, in session “Inflammatory endotyping: the macrophage across disease areas”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).