PT  - JOURNAL ARTICLE
AU  - Sinsamala, Robin Mzati
AU  - Marcon, Alessandro
AU  - Bertelsen, Randi
AU  - Janson, Christer
AU  - Holm, Mathias
AU  - Modig, Lars
AU  - Gislason, Thorarinn
AU  - Sigsgaard, Torben
AU  - Orru, Hans
AU  - Geels, Camilla
AU  - Frohn, Lise Marie
AU  - Brandt, Jørgen
AU  - Gomez Real, Francisco
AU  - Accordini, Simone
AU  - Markevych, Iana
AU  - Svanes, Cecilie
AU  - Johannessen, Ane
TI  - Preconception air pollution/greenness exposure and pregnancy outcomes:The Life-GAP Project
AID  - 10.1183/13993003.congress-2023.PA311
DP  - 2023 Sep 09
TA  - European Respiratory Journal
PG  - PA311
VI  - 62
IP  - suppl 67
4099  - http://erj.ersjournals.com/content/62/suppl_67/PA311.short
4100  - http://erj.ersjournals.com/content/62/suppl_67/PA311.full
SO  - Eur Respir J2023 Sep 09; 62
AB  - Background: Birth weight (BW) and preterm birth (PTB) increase the risk of impaired lung function. Decreasing the risk of low BW and PTB may improve respiratory health.Aim: To investigate the association of maternal exposure to air pollution and greenness during pregnancy with BW and PTB.Methods: We analysed data on 5434 children from 2742 mothers within the Respiratory Health in Northern Europe (RHINE) study. Exposure to greenness (Normalized Difference Vegetation Index, NDVI), modelled particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), ozone (O3), and black carbon (BC) were estimated for mothers based on residential address at each pregnancy. We used two-level (level 1: offspring; level 2: mother) linear and logistic regression models, while adjusting for centre, maternal age, education, smoking, body silhouette, and comorbidity.Results: Median (interquartile range, IQR) NDVI300m was 0.3(0.2-0.4), for pollutants in µg/m3 was 9.5(7.1-13.0), 16.4(11.1-21.3), 15.8(8.9-21.6), 49.5(45.2-54.0), and 0.6(0.4-0.8) for PM2.5, PM10, NO2, O3 and BC respectively. An IQR increase in NDVI300m was associated with an increase in BW of 29g (95%CI: 13-44), 23% lower odds of low BW (<2500g) (OR=0.77, 95% CI:0.64-0.94), and 14% increased odds of high BW (>4000g) (OR=1.14, 95% CI:1.02-1.26). The association was consistent after adjusting for air pollutants’ exposures or using different NDVI buffers(100m and 500m). No association of greenness exposure with PTB were observed. Air pollution exposure was associated with neither BW nor PTB.Conclusion: Maternal long-term exposure to greenness has a positive association with BW. Greenness could contribute to healthier pregnancies and improve lung health.FootnotesCite this article as: European Respiratory Journal 2023; 62: Suppl. 67, PA311.This abstract was presented at the 2023 ERS International Congress, in session “Inflammatory endotyping: the macrophage across disease areas”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).