PT  - JOURNAL ARTICLE
AU  - Nolasco, Santi
AU  - Portacci, Andrea
AU  - Campisi, Raffaele
AU  - Buonamico, Enrico
AU  - Pelaia, Corrado
AU  - Benfante, Alida
AU  - Triggiani, Massimo
AU  - Spadaro, Giuseppe
AU  - Caiaffa, Maria Filomena
AU  - Scioscia, Giulia
AU  - Detoraki, Aikaterini
AU  - Valenti, Giuseppe
AU  - Papia, Francesco
AU  - Tomasello, Alessandra
AU  - Crimi, Nunzio
AU  - Scichilone, Nicola
AU  - Pelaia, Girolamo
AU  - Carpagnano, Giovanna Elisiana
AU  - Crimi, Claudia
TI  - Effectiveness and Safety of Anti-IL-5/Rα Biologics in Eosinophilic Granulomatosis with Polyangiitis: A Two-Year Multicenter Observational Study
AID  - 10.1183/13993003.congress-2023.PA4753
DP  - 2023 Sep 09
TA  - European Respiratory Journal
PG  - PA4753
VI  - 62
IP  - suppl 67
4099  - http://erj.ersjournals.com/content/62/suppl_67/PA4753.short
4100  - http://erj.ersjournals.com/content/62/suppl_67/PA4753.full
SO  - Eur Respir J2023 Sep 09; 62
AB  - Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare vasculitis characterized by asthma, systemic manifestations, blood and tissue eosinophilia.Aim: To assess the effectiveness and safety of mepolizumab (anti-IL-5) and benralizumab (anti-IL-5Rα) in patients with EGPA for 24 months.Material and Methods: We conducted a multicenter observational study, including 49 patients (31 females, 63.3%) with EGPA treated with anti-IL-5/Rα biologics at 9 Italian outpatients’ facilities. Remission rates [Birmingham Vasculitis Activity Score (BVAS) =0 and prednisone (or equivalent) of ≤4.0 mg/day], corticosteroids (OCS) intake and respiratory outcomes were assessed.Results: Overall, BVAS score dropped from 6 (4-10) to 0 (0-0) (p<0.0001) at 24 months; 57.1% achieved remission after 24 months. The median OCS dose was reduced from 10 mg/day (5-20) to 2.5 mg/day (0.0-5) (p<0.0001) at 24 months; 69.6% of OCS-dependent patients lowered their daily dose by 75% and 28.3% discontinued these drugs. Multivariate analysis found that lower OCS intake [OR 0.8 (95% CI 0.67-0.93), p=0.0040] and higher blood eosinophil count [OR 1.002 (95% CI 1.0-1.003), p=0.0180] at baseline were independently associated with remission at 24 months. Asthma exacerbation dropped from 4 (3-5.8) to 0 (0-0.5) at 24 months (p<0.0001). The ACT score increased from 13.5 (10-17) to 22 (20-24) (p<0.0001) after 24 months. The pre-bronchodilator FEV1% improved from 77% (59.3-89.5) to 81.5% (71.5-100.5) (p<0.0001) at 24 months.Conclusions: These real-world data suggest that anti-IL-5/Rα biologics are effective and safe in the management of EGPA.FootnotesCite this article as: European Respiratory Journal 2023; 62: Suppl. 67, PA4753.This abstract was presented at the 2023 ERS International Congress, in session “Inflammatory endotyping: the macrophage across disease areas”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).