PT  - JOURNAL ARTICLE
AU  - Preisser, Alexandra Marita
AU  - Ströker, Lennart
AU  - Peldschus, Kersten
AU  - Herold, Robert
AU  - Harth, Volker
TI  - Decrease of DLCO and VC is associated with asbestos-related changes on TCT
AID  - 10.1183/13993003.congress-2023.PA3799
DP  - 2023 Sep 09
TA  - European Respiratory Journal
PG  - PA3799
VI  - 62
IP  - suppl 67
4099  - https://publications.ersnet.org//content/62/suppl_67/PA3799.short
4100  - https://publications.ersnet.org//content/62/suppl_67/PA3799.full
SO  - Eur Respir J2023 Sep 09; 62
AB  - Aims: To determine the essential parameters in pulmonary function and LD HR-TCT for secondary prevention of asbestos-related lung lesions.Methods: Data from spirometry, body plethysmography, DLCO, and TCT were retrospectively analyzed from 72 patients examined in 2017-2019. Subjects were divided into 4 subgroups based on the comorbidities of heart disease, obstructive ventilation disorders, lung function consistent with emphysema, or no other lung or heart disease. TCT were evaluated according to the International Classification of Occupational and Environmental Respiratory Diseases (ICOERD). In addition, asbestos-related parameters like subpleural curvilinear lines (SC), parenchymal bands (PB), and rounded atelectasis (RA) were quantified and included in appropriate scores. Correlations, Spearman's rho (ρ), Cohen’s κ, and accuracy were calculated.Results: VC shows only marginal reduction in the whole collective (mean 92% pred.), whereas DLCO and DLCO/VA show predominantly pathological values (70% and 87% pred., resp.). On CT scans, 79% (n=57) of patients present signs of pulmonary fibrosis, 81% pleural plaques. SC (54%) and PB (40%) are common. VC correlates with the score of pleural plaques (ρ=-0.273, p<0.05), DLCO shows better correlation with fibrosis score (ρ=-0.315, p<0.01). A third, newly developed score, which includes the extent of pleural plaques and additional SC, PB, and RA, shows correlations for both VC and DLCO (ρ= -0.283, -0.274; p<0.05), also including patients with concomitant diseases.Conclusions: When PB, SC, and RA are included in addition to pleural plaques, the correlation with VC and DLCO increases. Therefore, these parameters should also be quantified and used to assess disease severity.FootnotesCite this article as: European Respiratory Journal 2023; 62: Suppl. 67, PA3799.This abstract was presented at the 2023 ERS International Congress, in session “Inflammatory endotyping: the macrophage across disease areas”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).