TY - JOUR T1 - The role of circular RNAs in pulmonary hypertension JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00012-2022 VL - 60 IS - 6 SP - 2200012 AU - Md Khadem Ali AU - Katharina Schimmel AU - Lan Zhao AU - Chun-Kan Chen AU - Kamal Dua AU - Mark R. Nicolls AU - Edda Spiekerkoetter Y1 - 2022/12/01 UR - http://erj.ersjournals.com/content/60/6/2200012.abstract N2 - Circular RNAs (circRNAs) are endogenous, covalently circularised, non-protein-coding RNAs generated from back-splicing. Most circRNAs are very stable, highly conserved, and expressed in a tissue-, cell- and developmental stage-specific manner. circRNAs play a significant role in various biological processes, such as regulation of gene expression and protein translation via sponging of microRNAs and binding with RNA-binding proteins. circRNAs have become a topic of great interest in research due to their close link with the development of various diseases. Their high stability, conservation and abundance in body fluids make them promising biomarkers for many diseases. A growing body of evidence suggests that aberrant expression of circRNAs and their targets plays a crucial role in pulmonary vascular remodelling and pulmonary arterial hypertension (group 1) as well as other forms (groups 3 and 4) of pulmonary hypertension (PH). Here we discuss the roles and molecular mechanisms of circRNAs in the pathogenesis of pulmonary vascular remodelling and PH. We also highlight the therapeutic and biomarker potential of circRNAs in PH.This review evaluates the role and molecular mechanisms of circular RNAs in pulmonary hypertension with a view to research opportunities, clinical study and therapeutic potential https://bit.ly/3MTHrdd ER -