RT Journal Article
SR Electronic
T1 FeNO in a healthy population: normal ranges and contributing factors
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4523
DO 10.1183/13993003.congress-2022.4523
VO 60
IS suppl 66
A1 C Bal
A1 C Schiffers
A1 P Puchhammer
A1 O Sunanta
A1 M Breyer
A1 W Pohl
A1 S Hartl
A1 M Idzko
A1 R Breyer-Kohansal
YR 2022
UL http://erj.ersjournals.com/content/60/suppl_66/4523.abstract
AB Fractional exhaled nitric oxide (FeNO) is a type 2 inflammation marker used in the management of asthma. Current standards focus on thresholds to designate the presence and degree of local inflammation. However, epidemiological knowledge of FeNO values in general populations is needed to better understand the normal ranges and contributing factors.In this analysis 3110 healthy probands without any history of respiratory diseases, atopy, inhaled medication use, current smoking, obstructive lung function and/or bronchial reversibility, aged 6-82 years with valid FeNO testing were included from the Austrian LEAD study, a single-centred, observational, longitudinal, general population cohort. The mean values and associations of FeNO with anthropometrics, non-respiratory diseases, history including symptoms, exposures, inflammatory parameters, allergy, and lung function were assessed.FeNO levels were affected as seen in the stratification and stepwise linear regression analyses:Our data elucidate the considerable distribution of FeNO in both youth and adults of a large, respiratory healthy population, which is affected by factors like age, height, eosinophils, and lung function.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 4523.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).