TY - JOUR T1 - Transbronchial biopsy by radial probe endobronchial ultrasound followed by cryobiopsy using a novel 1.1-mm diameter cryoprobe JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2022.4423 VL - 60 IS - suppl 66 SP - 4423 AU - J S Eom AU - S H Kim AU - H S Chung Y1 - 2022/09/04 UR - http://erj.ersjournals.com/content/60/suppl_66/4423.abstract N2 - Background: The combination of radial probe endobronchial ultrasound (R-EBUS) and cryobiopsy for peripheral lung lesions (PLLs) improves the performance of transbronchial biopsy (TBB). We investigated the performance and safety of an additional cryobiopsy using a novel 1.1-mm diameter probe following conventional TBB using R-EBUS for the diagnosis of PLLs.Methods: Patients who underwent biopsy for the diagnosis of PLL ≤ 30 mm from April 2021 to November 2021 and received combined TBB using R-EBUS and sequential cryobiopsy with a 1.1-mm diameter probe were included in our study. All records were followed-up until April 2022.Results: Baseline characteristics for study patients (n = 110) are presented in Table 1. The overall diagnostic yield was 79%, which was significantly higher than 61% of TBB (P < 0.01). The diagnostic yield of subsequent cryobiopsy was 66% and cryobiopsy increased the overall diagnostic yield by 18%. There were significant differences in the surface area of the tissue between cryobiopsy (mean area, 19 mm2) and both TBB using 1.5-mm forceps (mean area, 3 mm2; P < 0.01) and 1.9-mm forceps (mean area, 4 mm2; P < 0.01). Complications were found in 10% of samples: pneumothorax (1%), infection (1%), and significant bleeding (8%). No patients developed life-threatening complications.Conclusions: Additional cryobiopsy using 1.1-mm diameter probe increased the diagnostic yield of TBB using R-EBUS by 18%. The overall diagnostic yield of combined procedures with TBB using R-EBUS and subsequent cryobiopsy was 79% for PLL ≤ 30 mm.Table 1.View this table:FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 4423.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -