@article {Eom4423, author = {J S Eom and S H Kim and H S Chung}, title = {Transbronchial biopsy by radial probe endobronchial ultrasound followed by cryobiopsy using a novel 1.1-mm diameter cryoprobe}, volume = {60}, number = {suppl 66}, elocation-id = {4423}, year = {2022}, doi = {10.1183/13993003.congress-2022.4423}, publisher = {European Respiratory Society}, abstract = {Background: The combination of radial probe endobronchial ultrasound (R-EBUS) and cryobiopsy for peripheral lung lesions (PLLs) improves the performance of transbronchial biopsy (TBB). We investigated the performance and safety of an additional cryobiopsy using a novel 1.1-mm diameter probe following conventional TBB using R-EBUS for the diagnosis of PLLs.Methods: Patients who underwent biopsy for the diagnosis of PLL <= 30 mm from April 2021 to November 2021 and received combined TBB using R-EBUS and sequential cryobiopsy with a 1.1-mm diameter probe were included in our study. All records were followed-up until April 2022.Results: Baseline characteristics for study patients (n = 110) are presented in Table 1. The overall diagnostic yield was 79\%, which was significantly higher than 61\% of TBB (P \< 0.01). The diagnostic yield of subsequent cryobiopsy was 66\% and cryobiopsy increased the overall diagnostic yield by 18\%. There were significant differences in the surface area of the tissue between cryobiopsy (mean area, 19 mm2) and both TBB using 1.5-mm forceps (mean area, 3 mm2; P \< 0.01) and 1.9-mm forceps (mean area, 4 mm2; P \< 0.01). Complications were found in 10\% of samples: pneumothorax (1\%), infection (1\%), and significant bleeding (8\%). No patients developed life-threatening complications.Conclusions: Additional cryobiopsy using 1.1-mm diameter probe increased the diagnostic yield of TBB using R-EBUS by 18\%. The overall diagnostic yield of combined procedures with TBB using R-EBUS and subsequent cryobiopsy was 79\% for PLL <= 30 mm.Table 1.View this table:FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 4423.This article was presented at the 2022 ERS International Congress, in session {\textquotedblleft}-{\textquotedblright}.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/60/suppl_66/4423}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }