PT  - JOURNAL ARTICLE
AU  - E Pacheco da Silva
AU  - M Ngutuka
AU  - O Dumas
AU  - L Orsi
AU  - P Lemire
AU  - J Quentin
AU  - I Pin
AU  - R Varraso
AU  - V Siroux
AU  - N Le Moual
TI  - Longitudinal associations of household use of cleaning agents and asthma symptoms
AID  - 10.1183/13993003.congress-2022.267
DP  - 2022 Sep 04
TA  - European Respiratory Journal
PG  - 267
VI  - 60
IP  - suppl 66
4099  - http://erj.ersjournals.com/content/60/suppl_66/267.short
4100  - http://erj.ersjournals.com/content/60/suppl_66/267.full
SO  - Eur Respir J2022 Sep 04; 60
AB  - Few epidemiological studies examined longitudinal associations of household use of cleaning products and asthma.The aim was to assess the associations of the evolution of household use of cleaning products with the asthma symptom score and its evolution over 8 years.Our study is based on 509 women (mean age: 51 years) participating in the last two surveys of the Epidemiological study on the Genetics and Environment of Asthma (EGEA2: 2003-2007 and EGEA3: 2011-2013). We determined the asthma symptom score (range 0-5) and the use of household cleaning products using standardised questionnaire data. The evolution of weekly use of irritant or spayed cleaning products (no weekly use at EGEA2-EGEA3 (ref); decreased; persistent; increased) was studied in association with the asthma symptom score at EGEA3 by negative binomial models and with the evolution in asthma symptoms between EGEA2-EGEA3 (asymptomatic stable (ref); symptomatic stable; improvement; incidence) by polytomous logistic regressions. Models were adjusted for age, smoking status, and body mass index, and accounted for familial dependence.Persistent and increased (40% and 16%, respectively) weekly use of irritants or sprays were associated with a higher risk of asthma symptoms at EGEA3 (MSR=1.41 [1.06-1.88] and 1.27[0.87-1.86], respectively) and with an increased risk of persistent asthma symptoms (symptomatic stable) over time (OR=2.80 [1.32-5.97] and 2.76 [1.05-7.24], respectively). No significant associations were observed with incidence nor between a decreased use of products and the improvement of symptoms.Persistent or increased weekly use of cleaning products over time may have an adverse effect on the evolution of respiratory health.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 267.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).