PT  - JOURNAL ARTICLE
AU  - Amado Diago, C A
AU  - Viejo Casas, A
AU  - Vazquez Bourgon, J
AU  - Agüero Calvo, J
AU  - Crespo Facorro, B
AU  - Ruiz Nuñez, M
AU  - Garastazu, R
TI  - Early alterations in lung function in a cohort of patients with non-affective psychotic disorder and a control group.
AID  - 10.1183/13993003.congress-2022.2239
DP  - 2022 Sep 04
TA  - European Respiratory Journal
PG  - 2239
VI  - 60
IP  - suppl 66
4099  - http://erj.ersjournals.com/content/60/suppl_66/2239.short
4100  - http://erj.ersjournals.com/content/60/suppl_66/2239.full
SO  - Eur Respir J2022 Sep 04; 60
AB  - Introduction: Patients with non-affective psychotic disorder (NAPD) smoke more and more intensely. Recent studies show that patients with normal spirometry but low DLCO are at higher risk for developing COPD with obstruction to airflow. The aim of this study is to evaluate the risk of having DLCO alterations in patients with NAPD compared with a control group.Methods: Patients with NAPD less of 60 years alod without COPD or asthma were compared with a sex, age and smoking habit matched control group. Demographic characteristics, mMRC dyspnea score, CAT score, forced spirometry and DLCO were recorded.Results: 172 subjects (97 Patients with NAPD Vs 75 controls) were included in the study. Main differences of both groups were NAPD pack-years were higher (14.4 (3.55-23.9) vs. 5.29 (0-14) p=0.001), lower DLCO (mL) 7033+/−2187 Vs. 8525+/−2374 p<0.001 and DLCO (%) 71.5+/−15.1 Vs. 84.9+/−15.1 p<0.001 were found in patients with NAPD, more subjects with DLCO <80% were found in patients with NAPD n(%) 65(69) Vs. 29(30.9) p<0.001.Univariate logistic regression analysis showed that NAPD (p<0.001), sex (p<0.001), pack-years (p=0.02), FVC (%) (p=0.002), FEV1 (%) (p<0.001) were predictors of DLCO<80% but not age (p=0.092), smoking status (p=0.082) or BMI (p=0.551). Multivariate logistic regression analysis showed that NAPD (p<0.001 OR 7.019 CI95% 2.555-19.281) and female sex (p<0.001 OR 27.229 95%IC 8.803-84.228) were independent risk factors for DLCO<80%.Conclusions: Patients with NAPD and females had early alterations in DLCO. These results suggest that early screening for lung disease should be encouraged in these patients.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 2239.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).