TY - JOUR T1 - Percentage of sleep time with increase in respiratory effort is a strong predictor of prevalent hypertension in obstructive sleep apnea patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2022.691 VL - 60 IS - suppl 66 SP - 691 AU - N Le-Dong AU - J Martinot AU - R Tamisier AU - J Pépin Y1 - 2022/09/04 UR - http://erj.ersjournals.com/content/60/suppl_66/691.abstract N2 - Rationale: Increase in respiratory effort (RE) is a key feature of obstructive sleep apnea (OSA) and is participating in sympathetic overactivity and remodeling of vascular walls. We aimed to evaluate the impact of percentage of sleep time in RE (RE_dt) as a predictor of prevalent hypertension (HT) in adults with OSA.Methods: A machine learning model was built to predict HT from clinical profiles including age, sex, BMI, conventional PSG indices and RE_dt derived from mandibular movement signals (Sunrise, Namur, Belgium).Results: In 1126 patients referred for suspected OSA (M/F ratio = 1.2; BMI = 31.4 ± 7.6; apnea hypopnea index (AHI) = 24.6 ± 20.9), HT prevalence was 30.8%. Percentage of TST spent in RE was significantly associated with a higher likelihood of prevalent HT (OR = 17.6; 95%CI: 9.7-31.9).The classification rule allows for predicting HT with high accuracy (85.9%). Shapley additive explanation process was conducted to assign a score to each feature values depending on their contribution to the prediction. This analysis (Figure) revealed that RE_dt was the best predictor among sleep test driven metrics, its contribution was even better than that of ODI, AHI or RDI.Conclusion: The percentage of sleep time spent with an increase in RE derived from mandibular movement signals appears as a new relevant metric to assess OSA impact in cardiovascular risk.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 691.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -