PT - JOURNAL ARTICLE AU - A C Trofor AU - I Buculei AU - M Dobrin AU - R I Cernat AU - L Trofor AU - O Melinte AU - C Vicol AU - E Stavarache TI - Biomarkers used to evaluate smoking in COPD patients AID - 10.1183/13993003.congress-2022.2079 DP - 2022 Sep 04 TA - European Respiratory Journal PG - 2079 VI - 60 IP - suppl 66 4099 - http://erj.ersjournals.com/content/60/suppl_66/2079.short 4100 - http://erj.ersjournals.com/content/60/suppl_66/2079.full SO - Eur Respir J2022 Sep 04; 60 AB - Introduction: Chronic obstructive pulmonary disease (COPD) is a complex disease with oxidative stress and inflammation playing an important role in its development and evolution, even after the patients quit smoking.Material and methods: The purpose of this study was to evaluate the biochemical (ASAT, ALT, urea, creatinine, glucose, uric acid, uric acid / creatinine UCR ratio) and hematological parameters for 53 patients (smokers, non-smokers, ex-smokers), depending on the smoking status (packs years -PY) and also identifying markers to evaluate tobacco exposure and the severity of COPD.Results and discussions: The Man-Whitney test showed a statistically significant difference in smokers vs non-smokers (COPD II and III stages) (p˂0.05) given by serum uric acid, urea and PY. In the smokers and ex- smokers groups, the statistical difference (p˂0.05) was indicated by serum uric acid and the number of eosinophils. The UCR ratio was positively correlated with the number of eosinophils (p˂0.05; r = 0.45) and serum glucose (p˂0.05; r = 0.50) for all 3 groups (smokers, non-smokers and ex-smokers). The discriminant analysis indicates a very good separation of the classes evaluated especially for smokers and non-smokers, respectively ex-smokers and non-smokers (Figure 1) and also shows a direct dependence between nicotine consumption (PY), serum uric acid levels and evaluation of the UCR ratio.Conclusions: Evaluation of serum uric acid as well as the ratio of UCR in patients with or without nicotine dependence shows a statistically significant difference between smokers and non-smokers in terms of oxidative stress and could indicate a direct association with the severity of COPD.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 2079.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).