RT Journal Article SR Electronic T1 ¿Has Mortality from COPD Decreased in Spain in the Last Two Decades? JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 4326 DO 10.1183/13993003.congress-2022.4326 VO 60 IS suppl 66 A1 G Ramirez Rodriguez A1 A Quesada Quesada A1 A Menendez Lobo A1 A Romero Linares A1 C Rodriguez Rivas A1 P Romero Palacios A1 B Alcazar Navarrete YR 2022 UL http://erj.ersjournals.com/content/60/suppl_66/4326.abstract AB Introduction: COPD is the third leading cause of death globally. In Spain it has been observed a decreased in COPD mortality rates in the latest years. However, it is unknown whether this decline has happened equally among different regions in Spain. The aim of this study is to compare the COPD mortality rates among the Spanish regions during the period 1999-2019Methods: We obtained the age-adjusted mortality rates/100.000 people from both men and women form the period between 1999- 2019 after consulting the Statistic Portal from the Spanish Health Ministry. We implemented a joint point regression analysis to provide an estimation of APC (annual percent change) in mortality rates as well as to identify potential changes in the slope. Statistical significance was considered for a p value<0.05Results: During the study period COPD age- adjusted mortality rates in Spain decreased from 28.77 deaths/100.000 in 1999 to 12.14/100.000 people in 2019, with a mean APC of 3.8%. Among male, the regions where more pronounced reductions in COPD mortality were found were Basque Country (APC -5,49%, 95% CI -5.01, -6.02) and Asturias (APC -5.41%, 95% CI -5.9, -4.9). Among women, COPD mortality rates have decreased in two phases with a change in trend by 2006. The regions with more pronounced reductions in mortality rates were Murcia (APC -4.80%, 95% CI -6.0, -3.6) and Galicia (APC -4.20%, 95% CI -4.9, -3.5).Conclusions: Age- adjusted COPD mortality rates have decreased heterogeneously among regions in Spain in men but also in women during the last 20 years. This data should be applied for benchmarking among healthcare services in Spain.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 4326.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).