PT  - JOURNAL ARTICLE
AU  - A Mola Ausiró
AU  - Y Galea Colón
AU  - N Angrill Sellés
AU  - M Baiges Badia
AU  - S Mora Acosta
AU  - E Barbeta Sanchez
AU  - A Mola Ausiró
TI  - Lung function at 12-18 months in patients with ARDS due to SARS-CoV-2 pneumonia
AID  - 10.1183/13993003.congress-2022.1907
DP  - 2022 Sep 04
TA  - European Respiratory Journal
PG  - 1907
VI  - 60
IP  - suppl 66
4099  - http://erj.ersjournals.com/content/60/suppl_66/1907.short
4100  - http://erj.ersjournals.com/content/60/suppl_66/1907.full
SO  - Eur Respir J2022 Sep 04; 60
AB  - Research Questions: To describe lung function at 12-18 months in patients with pneumonia and adult respiratory distress syndrome (ARDS) due to SARS-CoV2 with radiological sequelaeMaterial and methods: Observational study of patients with pneumonia and ARDS due to SARS-CoV2 who required admission to the ICU/IRCU of Granollers Hospital between March and May 2020. We collected clinical, chest CT, spirometry and DLCO data. The dyspnoea is defined according to the modified Medical Research Council (mMRC) scale, an altered spirometry is considered when FVC and/or FEV1<80%, and the presence of a reticular patern/fibrosis is valued as radiological sequelaeResults: Of a total of 109 admitted patients, 23 died during hospital stay. Of the survivors, 71 patients were followed up in outpatient clinics after 1 year. Of these, 44 presented radiological sequelae on chest CT at 1 year after discharge (6, pulmonary fibrosis). 70.5% were men, mean age of 63.8 (±9.08) years and 56.8% with smoking history At 1 year, 39% had MMRC dyspnoea grade 0, 43.9% grade 1, and 17.1% grade 2 or 3 32.5% had normal spirometry and DLCO>80%, 35% normal spirometry and DLCO<80%, and 17.5% altered spirometry and DLCO<80%. 42.5% had a DLCO between 60-79% and 10% between 40-59% We observed that 53.3% of patients with dyspnoea grade 0 and 54.2% of patients with dyspnoea grade >1 had DLCO<80% [p= 0'959] and that 75% of patients with fibrosis and 50% of patients with reticular pattern had DLCO<80% At 18 months, a drop in DLCO>15% was observed in 3/30 patients (10%)Conclusions: At 1 year, 32.5% of patients had normal Spirometry and DLCO>80%. No relationship was observed between degree of dyspnoea and DLCO. No significant drop in DLCO was regarded at 18 monthsFootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 1907.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).