TY - JOUR T1 - The role of transcutaneous carbon dioxide measurement during exercise. JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2022.2294 VL - 60 IS - suppl 66 SP - 2294 AU - R Ong-Salvador AU - P Jak AU - R Bekkema AU - J Van Den Aardweg Y1 - 2022/09/04 UR - http://erj.ersjournals.com/content/60/suppl_66/2294.abstract N2 - Rationale: Arterial blood gas (ABG) sampling is the gold standard of measuring arterial carbon dioxide pressure (PaCO2). However, it is invasive and has potential for complications. Since transcutaneous monitoring of carbon dioxide (TcCO2) is easy to perform and non-invasive, it could be an alternative to PaCO2.Objective: We hypothesized that TcCO2 could be used to discriminated between hypocapnia and hypercapnia during exercise.Methods: This cross-sectional study included 124 outpatient referrals for cardiopulmonary exercise testing with ABG at rest and at peak exercise. The TcCO2 was measured continuously using SENTEC V-STATSTM. ABG was marked at the moment of extraction. The tests were grouped into rest (n= 65), peak exercise (n= 112) and both (n= 53) based on ABG collected. We used PaCO2 value of 1.3 kPa (4.0 - 5.3 kPa) to discriminate between hypocapnia and hypercapnia at peak exercise.Results: The Bland-Altman analysis of PaCO2 and TcCO2 at rest showed a mean difference of -0.01 kPa with limits of agreement (LOA) -0.73 – 0.72. At peak exercise, mean difference is -0.07 kPa with LOA -0.82 – 0.67. The TcCO2 showed a strong and significant correlation with PaCO2 at rest and peak exercise (r= 0.768, p=<0.0001 and r=0.807, p=<0.0001, respectively). The change in TcCO2 from rest to peak exercise showed a moderate and significant correlation with the change in PaCO2 (r= 0.61, p=<0.0001). In 70% of the cases, the direction of change in TcCO2 is the same as in PaCO2.Conclusion: The mean difference between PaCO2 and TcCO2 is small. But the range of 1.49 kPa at peak exercise is higher than the predetermined acceptable range. Using TcCO2 alone does not discriminate between hypocapnia or hypercapnia during exercise.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 2294.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -