PT - JOURNAL ARTICLE AU - G Steinhilber AU - I Vogiatzis AU - B Salvi AU - L Bertacchini AU - I Favero AU - M Venturelli AU - M Paneroni AU - M Vitacca TI - Tolerability and safety of high-intensity continuous and intermittent exercise in COVID-19 AID - 10.1183/13993003.congress-2022.2472 DP - 2022 Sep 04 TA - European Respiratory Journal PG - 2472 VI - 60 IP - suppl 66 4099 - http://erj.ersjournals.com/content/60/suppl_66/2472.short 4100 - http://erj.ersjournals.com/content/60/suppl_66/2472.full SO - Eur Respir J2022 Sep 04; 60 AB - Aim: We assessed safety of high-intensity [IV1] constant-load exercise (CLE) and intermittent exercise (HIIT) in 14 post-severe-COVID-19 patients (63±13 years; 78.6% male; BMI: 28±5, without comorbidities) between July 2020 and April 2021 after 55±22 days of COVID-induced acute respiratory failure.Methods: The crossover study balanced exercise intensity between CLE at 70% of peak work rate (WRpeak) to the limit of tolerance (Tlim) and HIIT including 1 min exercise at 100% WRpeak, alternated with 1 min at 40% WRpeak to Tlim. Gas exchange, ventilation, electrocardiography and symptoms were assessed.Results: Exercise endurance time and total work output were not different between HITT and CLE (Table 1). At Tlim, none of the ventilatory or cardiovascular responses differed between HITT and CLE and there was no difference in the intensity of symptoms (Table 1).View this table:Conclusions: Individuals with ongoing symptomatic COVID-19 could safely undertake high intensity exercise performed continuously or intermittently.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 2472.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).