PT  - JOURNAL ARTICLE
AU  - Arigliani, M
AU  - Chaudhry, S
AU  - Brugha, R
AU  - Suri, R
AU  - Aurora, P
TI  - Does infant lung function affect clinical management in children with cystic fibrosis?
AID  - 10.1183/13993003.congress-2022.4532
DP  - 2022 Sep 04
TA  - European Respiratory Journal
PG  - 4532
VI  - 60
IP  - suppl 66
4099  - http://erj.ersjournals.com/content/60/suppl_66/4532.short
4100  - http://erj.ersjournals.com/content/60/suppl_66/4532.full
SO  - Eur Respir J2022 Sep 04; 60
AB  - Introduction: At our centre, infant lung function (ILF) is routinely performed in children with cystic fibrosis (CF). Research question: do ILF results affect clinical management?Methods: Mono-centre retrospective cohort analysis of subjects with CF born between 2014 and 2018. Z-scores for SF6 Lung Clearance Index (zLCI), plethysmographic FRC (zFRCpleth) and zFEV0.5 were derived. The closest clinical encounter following each ILF data point was reviewed to evaluate whether there were changes in clinical management and why.Results: Following 95 ILF tests there were 10 changes in management, but only one of these was for abnormal ILF results alone. In the other 9 cases there were also increased symptoms and/or abnormal microbiology. See table for full resultsView this table:Conclusion: This analysis did not demonstrate change in clinical management following ILF results alone. Prospective studies involving weighting of different factors are required to assess the utility of ILF.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 4532.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).