RT Journal Article
SR Electronic
T1 Small airway dysfunction detected by oscillometry in asthma, COPD, and asthma-COPD overlap
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1595
DO 10.1183/13993003.congress-2022.1595
VO 60
IS suppl 66
A1 T Shirai
A1 K Hirai
A1 Y Gon
YR 2022
UL http://erj.ersjournals.com/content/60/suppl_66/1595.abstract
AB Background: The ATLANTIS cohort revealed that the difference between respiratory system resistance at 5 Hz and 20 Hz (R5−R20), respiratory system reactance at 5 Hz (X5), and area of reactance (AX) were strong contributors to small airway dysfunction (SAD), with high prevalence in asthma compared to other measures (Postma 2019). However, the relevance of SAD in obstructive lung diseases is unknown.Aims: To assess the difference in these oscillometric parameters between asthma, asthma-COPD overlap (ACO), and COPD.Methods: Subjects included patients with asthma (n = 170), ACO (n = 114), or COPD (n = 60). Oscillometry was measured and compared among the patients.Results: R5−R20, X5, and AX values were significantly lower in ACO and COPD patients than in asthma patients. However, there was no difference between ACO and COPD patients. The median R5−R20, X5 (cmH2O/L/s), and AX (cmH2O/L) were as follows: asthma, 0.60, −0.63, 2.40; ACO, 0.81, −1.06, 5.35; and COPD, 0.81, −1.04, 5.50, respectively (Figure 1). Multinomial logistic regression analysis revealed that the odds ratio for ACO vs. asthma was R5−R20, 0.54; X5, 1.44; and AX, 0.95, and ACO vs. COPD was R5−R20, 1.06; X5, 0.90; and AX, 1.01. Based on the cutoff value of 0.07 kPa/L/s (0.714 cmH2O/L/s) for SAD (Lipworth 2014), the prevalence of patients with SAD was 70 (41%) in asthma, 62 (54%) in ACO, and 35 (58%) in COPD patients.Conclusions: ACO and COPD patients have more severe SAD than asthma patients.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 1595.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).