RT Journal Article
SR Electronic
T1 Prolonged exposure to heat does not affect clinical and biochemical characteristics in patients with cystic fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3137
DO 10.1183/13993003.congress-2022.3137
VO 60
IS suppl 66
A1 P Anagnostopoulou
A1 P Kouis
A1 K Pantavou
A1 A Michanikou
A1 A Matthaiou
A1 K Ioakim
A1 L Sophocleous
A1 G Nikolopoulos
A1 P Yiallouros
YR 2022
UL http://erj.ersjournals.com/content/60/suppl_66/3137.abstract
AB Dehydration and electrolyte imbalance are key clinical characteristics of cystic fibrosis (CF), especially when patients are exposed to high temperatures. However, the effect of prolonged heat exposure on clinical and biochemical status of patients with CF is unknown.In Cyprus, an island with extreme heat during summer, we used wearable sensors to monitor ambient temperature exposure and physical activity in patients with CF and control individuals for 2 weeks during three periods (summer, early fall, late fall). At the end of each period, all participants were clinically assessed measuring anthropometrics, blood pressure, heart rate, spirometry, serum electrolytes (Na+, K+, Cl-), and serum osmolality.We included 18 patients with CF, median age (IQR) 17.5 (8.4-23.3), and 18 controls, 46.7 (33.6-53.8) in the study. For each period heat exposure and physical activity did not differ between patients and controls. Within the three periods, patients had similar clinical parameters (BMI, total body water, blood pressure, heart rate and FEV1). During summer (min-max T: 23-40°C) no difference was seen between patients and controls in serum electrolytes (for Na+ p=0.3, for K+ p=0.28, for Cl- p=0.44) and serum osmolality (p=0.44). In a mixed model, different temperature exposure between the three periods did not influence patients’ weight and BMI variability, heart rate, blood pressure, FEV1, serum electrolytes and serum osmolality.Our data show that prolonged exposure to heat conditions did not impact the clinical and biochemical profile of patients with CF. Larger studies are needed to confirm these findings and investigate factors that could modulate heat stress in CF.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 3137.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).