RT Journal Article
SR Electronic
T1 Proadrenomedullin and copeptin are more sensitive and specific biomarkers for the prediction of mortality in stable COPD than fibrinogen: An analysis of the COSYCONET study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4292
DO 10.1183/13993003.congress-2022.4292
VO 60
IS suppl 66
A1 S Fähndrich
A1 S Teuteberg
A1 C Herr
A1 H Watz
A1 B Waschki
A1 F C Trudzinski
A1 A Omlor
A1 P Alter
A1 F Seiler
A1 F Biertz
A1 T Welte
A1 H Kauczor
A1 R A Jörres
A1 C F Vogelmeier
A1 R Bals
A1 D Stolz
YR 2022
UL http://erj.ersjournals.com/content/60/suppl_66/4292.abstract
AB Rationale: Chronic obstructive disease (COPD) is one of the most common respiratory diseases caused by exogenous noxae. Multiple comorbidities are characteristic of this chronic systemic disease. The FDA-approved biomarker for predicting disease prognosis competes with other (not approved) biomarkers such as proadrenomedullin and copeptin.Methods: We compared sensitivity and specificity of these biomarkers using the data from the German COSYCONET (COPD and Systemic Consequences - Comorbidities Network) cohort study. We analyzed the suitability of the biomarkers for the prediction of mortality in a multiple COX regression analysis. We considered as confounder: Age, sex, numerous confounders for COPD, cardiovascular risk factors, and manifest cardiovascular diseases.Results: Plasma samples were measured of more than thousand patients with stable COPD (GOLD 0-4, GOLD A-D) from the German COPD cohort study COSYCONET.In Cox regression analyses including adjustments for COPD assessments, cardiovascular risk factors and cardiovascular diseases proadrenomedullin and copeptin predict significantly all-cause mortality in contrast to fibrinogen. The ROC analysis showed a more favorable AUC for the biomarkers adrenomedullin (AUC 0.664) and copeptin (0.632) compared to fibrinogen (0.537). The combination of quality of life scores CAT and MRC did not result in a marked increase in sensitivity and specificity.Conclusions: Proadrenomedullin and copeptin are better predictors for all-cause mortality in stable COPD than fibrinogen.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 4292.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).