TY - JOUR T1 - Immunoglobulin G4-related thoracic disease: clinical and radiological findings of an eastern mediterranean cohort JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2022.216 VL - 60 IS - suppl 66 SP - 216 AU - A Alkan Öncel AU - G Durhan AU - G K Yardimci AU - U Ozden Sertcelik AU - B Farisogullari AU - M Ariyurek AU - O Karadag AU - D Koksal Y1 - 2022/09/04 UR - http://erj.ersjournals.com/content/60/suppl_66/216.abstract N2 - Background and Aim: Thoracic involvement of Immunoglobulin G4-related disease (IgG4-RD) is relatively rare and can be easily overlooked due to its asymptomatic nature. This study aimed to determine the frequency and patterns of thoracic involvement of patients with IgG4-RD.Materials and Methods: 90 patients (male/female: 47/43, mean age: 57.7±15.5 years) with IgG4-RD were reviewed retrospectively. All computed tomography (CT) scans were re-evaluated by two thoracic radiologists and IgG4-related thoracic disease was assessed on four compartments: Mediastinum, pulmonary parenchyma, airways, and pleura. IgG4-related thoracic disease was categorized as: definite, highly probable, probable and possible.Results: 64 patients had undergone at least one thorax CT examination and 18 (28%) were recorded to have IgG4-related thoracic disease. The rate of IgG4-related thoracic disease increased by 20% and reached a ratio of 48.4% (n=31) after re-evaluating registry data dedicatedly for thoracic findings. Mediastinum was the most frequently involved compartment in 16 (51.6%) patients. Other organ involvements were more prevalent and IgG4 levels were higher in patients with thoracic involvement. Eosinophils were significantly elevated in patients with thoracic involvement (p=0.023).Conclusion: IgG4-related thoracic disease is heterogeneous and likely underestimated. Mediastinum is the most frequently involved compartment. IgG4-related thoracic disease should be evaluated at initial diagnosis. Elevated serum IgG4 levels and eosinophils, increased number of organ involvements can be indicators for thoracic involvement.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 216.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -