RT Journal Article
SR Electronic
T1 Can FDG-PET/CT imaging be used to prognosticate in Interstitial Lung Disease? A prospective study of the relationship between FDG-PET/CT measurements and quality of life.
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2473
DO 10.1183/13993003.congress-2022.2473
VO 60
IS suppl 66
A1 Jordon, L
A1 Ganeshan, B
A1 Nadeem, I
A1 Hoy, L
A1 Mahdi, N
A1 Porter, J
A1 Groves, A
A1 Win, T
A1 Nadeem, I
YR 2022
UL http://erj.ersjournals.com/content/60/suppl_66/2473.abstract
AB Introduction: Interstitial lung diseases (ILDs) are a heterogeneous group of progressive lung conditions. Tools to accurately prognosticate are lacking.Positron Emission Tomography (PET) CT imaging offers a non-invasive measure of tissue metabolic activity and shows potential for use in ILD monitoring.The aim of this study was to investigate the relationship between baseline FDG-PET/CT signal and quality of life (QOL) at diagnosis and longitudinally over 4 years to determine the utility of PET-CT in ILD prognostication.Methods: 193 patients with ILD were prospectively recruited and categorised into Idiopathic Pulmonary Fibrosis (IPF; 94 patients) and Non-IPF (99 patients) subgroups.FDG-PET/CT imaging was performed at baseline with maximum Standardised Uptake Value (SUVmax) and Tissue-to-Background Ratio (TBR) calculated for each patient.QOL measures were obtained using the St George’s Respiratory Questionnaire (SGRQ) at baseline and at 12, 24 and 48 months.Results: In our overall ILD population, and in the IPF and non-IPF subgroups, there was positive correlation between total SGRQ scores and SUVmax at baseline (rs=0.219, 0.187 and 0.320 respectively, p<0.005), but no relationship between baseline SUVmax or TBR and change in SGRQ scores at 12, 24 or 48 months.There was no significant change from baseline SGRQ scores for both subgroups at 12 and 24 months. At 48 months, a significant QOL deterioration was seen for the IPF group (t=-3.1,p=0.002) and an improvement for the non-IPF group (t=2.0,p=0.005). By 48 months, 78.7% of the IPF group and 46.5% of the non-IPF group had died.Conclusions: FDG-PET/CT measurements SUVmax and TBR correlate with baseline QOL but are not predictive of change in QOL over 4 years.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 2473.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).