PT  - JOURNAL ARTICLE
AU  - Wu, J
AU  - Xu, J J
AU  - Nohra, C
AU  - Vasileva, A
AU  - Binnie, W M
AU  - Shapera, S
AU  - Fisher, J
AU  - Ryan, C
AU  - Mcinnis, M
AU  - Hantos, Z
AU  - Chow, C
TI  - Characterization of Idiopathic Pulmonary Fibrosis (IPF) and Combined Pulmonary Fibrosis and Emphysema (CPFE) using Respiratory Oscillometry
AID  - 10.1183/13993003.congress-2022.1232
DP  - 2022 Sep 04
TA  - European Respiratory Journal
PG  - 1232
VI  - 60
IP  - suppl 66
4099  - http://erj.ersjournals.com/content/60/suppl_66/1232.short
4100  - http://erj.ersjournals.com/content/60/suppl_66/1232.full
SO  - Eur Respir J2022 Sep 04; 60
AB  - Introduction: Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung diseases (ILD), while combined pulmonary fibrosis and emphysema (CPFE) is a distinct entity with upper lobe emphysema and lower lobe fibrosis, occurring mostly in men with > 40 pack years of smoking. While pulmonary function tests (PFTs) are used to determine the severity and monitor disease progression, they are a poor measure of lung elastance and compliance, and do not readily distinguish between IPF and CPFE. Respiratory oscillometry (Osc) performed during tidal breathing, is exquisitely sensitive respiratory mechanics but has not been well studied in ILD.Objective: To characterize IPF and CPFE using Osc.Methods: Patients with IPF and CPFE diagnosed according to ATS/ETS guidelines, were prospectively enrolled for paired PFTs-Osc and six-minute walk test (6MWT). Comparisons between IPF and CPFE were performed using the Student’s T-test.Results: 201 IPF (70F, 131M; median age=65.2) and 26 CPFE (7F, 19M; median age=73.1) patients were enrolled from Sept 2019-Dec 2021. Osc was significantly different between IPF and CPFE, particularly in the reactance (X) measurements (p<0.05 for all) of X5in (mean inspiratory X at 5Hz) and the intrabreath metrics, XeI (X at end inspiration) and AXV (area of X-volume loop). In contrast, %predicted diffusing capacity was the only standard PFT parameter that was significantly different between the 2 groups. CPFE patients also had lower absolute and % predicted 6MWT (p<0.01).Conclusion: These findings suggest that Osc can provide information to distinguish IPF from CPFE that is not available with standard PFTs.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 1232.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).