PT  - JOURNAL ARTICLE
AU  - Crater, G D
AU  - Gaucher, G
AU  - Harvey, M
AU  - Ravenelle, F
TI  - INV-101, a cannabinoid receptor-1 inverse agonist, reduces fibrosis in a bleomycin mouse model of IPF
AID  - 10.1183/13993003.congress-2022.171
DP  - 2022 Sep 04
TA  - European Respiratory Journal
PG  - 171
VI  - 60
IP  - suppl 66
4099  - https://publications.ersnet.org//content/60/suppl_66/171.short
4100  - https://publications.ersnet.org//content/60/suppl_66/171.full
SO  - Eur Respir J2022 Sep 04; 60
AB  - Intro:INV-101 is a peripherally acting Cannabinoid receptor-1 inverse agonist under development for the treatment of Idiopathic Pulmonary Fibrosis (IPF). CB1 antagonists / inverse agonists have shown efficacy in prevention of fibrosis in bleomycin and radiation fibrosis models. Here we report the efficacy of INV-101 in a treatment model of IPF.Methods: 6-week-old female C57BL/6 mice were given bleomycin (3 mg/kg) intratracheally via Microsprayer to induce PF on Day 0. Administration of oral INV-101 (10 mg/kg/day) commenced on day 7 for 14 days. Nintedanib (100 mg/kg/day), was used as a positive control. On Day 21, Animals were sacrificed, and lungs were fixed.Results: INV-101 reduced Ashcroft score (1.4±0.8 p=0.02) when compared to vehicle (2.7±0.6) similar to nintedanib (1.8±1.2). There was no significant difference in lung hydroxyproline scores with either INV-101 or nintedanib. Similar to nintedanib, INV-101 showed a trend in reducing total BAL cell count. No deaths due to bleomycin were noted in any groups.Conclusion: INV-101 reduced Ashcroft score in a manner similar to nintedanib. Further work to understand the potential role of this new generation CB-1 inverse agonist in treating pulmonary fibrosis is warranted.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 171.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).