RT Journal Article
SR Electronic
T1 Usefulness of the early combination of non-invasive respiratory therapies in patients with COVID-19
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1644
DO 10.1183/13993003.congress-2022.1644
VO 60
IS suppl 66
A1 J R Teran Tinedo
A1 P Mariscal Aguilar
A1 M Lorente González
A1 E Cano Sanz
A1 J Hernández Núñez
A1 M A Ortega Fraile
A1 D Laorden Escudero
A1 I De La Calle-Gil
A1 M C Plaza Moreno
A1 D Carballo López
A1 B Gallego Rodríguez
A1 M Calderon Alcalá
A1 A Latif Essa
A1 A Zevallos Villegas
A1 S Gholamian Ovejero
A1 M Churruca Arróspide
A1 M Valle Falcones
A1 E M Saiz Lou
A1 C Rodríguez Calle
A1 P Landete Rodríguez
YR 2022
UL http://erj.ersjournals.com/content/60/suppl_66/1644.abstract
AB Aim: To determine the effect of the early combination of high flow nasal cannula (HFNC) plus continuous positive airway pressure (CPAP) regarding endotracheal intubation (ETI) and 30-day mortality in patients with SARS-CoV-2 pneumonia.            Methods: Observational study of patients admitted to the intermediate respiratory care unit (IRCU) who received HFNC+CPAP. Two groups were formed according to the time of starting the combined therapy: Early HFNC+CPAP (first 24 h - EHC) and Late HFNC+CPAP (after 24 h - LHC). A multivariate analysis was performed to establish the strength of the association with ETI and 30-day mortality.Results: 780 patients were included (502 male, mean age 56.5 ± 12.9 years). Table 1 shows the baseline characteristics. 273 patients were subjected to ETI, 32.9% in the EHC group vs 38.9% in the LHC group (p 0.05). 30-day mortality was 8.2% in the EHC vs 15.5% LHC (p 0.02). Table 2 shows the multivariate analysis.Conclusions: The combination of HFNC+CPAP, especially in the first 24 hours after IRCU admission, is a useful tool in the management of SARS-CoV-2 pneumonia.View this table:View this table:FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 1644.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).