RT Journal Article
SR Electronic
T1 Sex-related differences and FEV1 decline among COPD patients: the French Palomb cohort
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4514
DO 10.1183/13993003.congress-2022.4514
VO 60
IS suppl 66
A1 N Jestin-Guyon
A1 E H Ouaalaya
A1 A Bernady
A1 E Berteaud
A1 J Casteigt
A1 L Falque
A1 F Le Guillou
A1 J Moinard
A1 M Molimard
A1 L Nguyen
A1 C Nocent
A1 A Ozier
A1 M Staali
A1 C Raherison-Semjen
YR 2022
UL http://erj.ersjournals.com/content/60/suppl_66/4514.abstract
AB Background: Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of mortality worldwide and its prevalence among women increased in the past decade in developed countries mainly due to tobacco consumption and other risk factors. This study investigates sex-related differences of FEV1 decline in a real-life cohort.Methods: Prospective multi-centered study of COPD patients recruited between 2013 and 2022. Information collected at inclusion and visits: smoking status, symptoms, clinical characteristics, comorbidities. The evolution of FEV1 was analyzed in patients with 2 or more measures.Results: 3,228 patients were enrolled in the study. Women (36.5%) were younger, had lower BMI and were more current smokers than men patients (p<0.001). Regarding symptoms women had more dyspnea (p<0.009) and exacerbations (p<0.001). No sex differences were found for chest tightness and cough, except for more expectorations among men (p<0.004). For comorbidities men had more hypertension, ischemic heart disease, diabetes and less anxiety, depression, osteoporosis and asthma (p<0.001). Men had a lower predicted FEV1 (57.4%) than women (60.5%) (p<0.001) and a more severe COPD according to GOLD classification (p=0.005). No sex-related differences was observed for FEV1 decline.Conclusion: This study demonstrates differences on characteristics and some clinical aspects of women and men with COPD.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 4514.This article was presented at the 2022 ERS International Congress, in session “-”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).