TY - JOUR T1 - Cancer risk associated with alpha-1-antitrypsin deficiency: only large registries will give us the answer JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01289-2022 VL - 60 IS - 4 SP - 2201289 AU - Miriam Barrecheguren AU - Marc Miravitlles Y1 - 2022/10/01 UR - http://erj.ersjournals.com/content/60/4/2201289.abstract N2 - Alpha-1-antitrypsin (AAT) is a serine proteinase inhibitor, the main function of which is to inhibit neutrophil elastase (NE) activity, but it also regulates several immune and inflammatory responses [1]. Deficiency of the protein (alpha-1-antitrypsin deficiency or AATD) is a well-known genetic condition associated with an increased risk of developing pulmonary emphysema and liver disease [2, 3]. It has been hypothesised that it is associated with other respiratory diseases, such as asthma or bronchiectasis [4], and it has also been linked with a potential increase of the risk of some types of cancer, although the information available is sparse [5].Alpha-1-antitrypsin deficiency has been linked with a potential increase of the risk of some types of cancer; international prospective registries are key to shed light on this important aspect https://bit.ly/3AIApov ER -