%0 Journal Article %A Luis A. Torres %A Kristine E. Lee %A Gregory P. Barton %A Andrew D. Hahn %A Nathan Sandbo %A Mark L. Schiebler %A Sean B. Fain %T Dynamic contrast enhanced MRI for the evaluation of lung perfusion in idiopathic pulmonary fibrosis %D 2022 %R 10.1183/13993003.02058-2021 %J European Respiratory Journal %P 2102058 %V 60 %N 4 %X Background The objective of this work was to apply quantitative and semiquantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) methods to evaluate lung perfusion in idiopathic pulmonary fibrosis (IPF).Methods In this prospective trial 41 subjects, including healthy control and IPF subjects, were studied using DCE-MRI at baseline. IPF subjects were then followed for 1 year; progressive IPF (IPFprog) subjects were distinguished from stable IPF (IPFstable) subjects based on a decline in percent predicted forced vital capacity (FVC % pred) or diffusing capacity of the lung for carbon monoxide (DLCO % pred) measured during follow-up visits. 35 out of 41 subjects were retained for final baseline analysis (control: n=15; IPFstable: n=14; IPFprog: n=6). Seven measures and their coefficients of variation (CV) were derived using temporally resolved DCE-MRI. Two sets of global and regional comparisons were made: control versus IPF groups and control versus IPFstable versus IPFprog groups, using linear regression analysis. Each measure was compared with FVC % pred, DLCO % pred and the lung clearance index (LCI % pred) using a Spearman rank correlation.Results DCE-MRI identified regional perfusion differences between control and IPF subjects using first moment transit time (FMTT), contrast uptake slope and pulmonary blood flow (PBF) (p≤0.05), while global averages did not. FMTT was shorter for IPFprog compared with both IPFstable (p=0.004) and control groups (p=0.023). Correlations were observed between PBF CV and DLCO % pred (rs= −0.48, p=0.022) and LCI % pred (rs= +0.47, p=0.015). Significant group differences were detected in age (p<0.001), DLCO % pred (p<0.001), FVC % pred (p=0.001) and LCI % pred (p=0.007).Conclusions Global analysis obscures regional changes in pulmonary haemodynamics in IPF using DCE-MRI in IPF. Decreased FMTT may be a candidate marker for IPF progression.DCE-MRI quantitative perfusion and semiquantitative transit time metrics identified regional deficits in IPF lung disease relative to healthy control subjects and in IPF progression https://bit.ly/3swKH6r %U https://erj.ersjournals.com/content/erj/60/4/2102058.full.pdf