TY - JOUR T1 - The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01821-2021 VL - 60 IS - 2 SP - 2101821 AU - Jenna McNeill AU - Ariel Chernofsky AU - Matthew Nayor AU - Farbod N. Rahaghi AU - Raul San Jose Estepar AU - George Washko AU - Andrew Synn AU - Ramachandran S. Vasan AU - George O'Connor AU - Martin G. Larson AU - Jennifer E. Ho AU - Gregory D. Lewis Y1 - 2022/08/01 UR - http://erj.ersjournals.com/content/60/2/2101821.abstract N2 - Background Cardiorespiratory fitness is not limited by pulmonary mechanical reasons in the majority of adults. However, the degree to which lung function contributes to exercise response patterns among ostensibly healthy individuals remains unclear.Methods We examined 2314 Framingham Heart Study participants who underwent cardiopulmonary exercise testing (CPET) and pulmonary function testing. We investigated the association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC and diffusing capacity of the lung for carbon monoxide (DLCO) with the primary outcome of peak oxygen uptake (V′O2) along with other CPET parameters using multivariable linear regression. Finally, we investigated the association of total and peripheral pulmonary blood vessel volume with peak V′O2.Results We found lower FEV1, FVC and DLCO were associated with lower peak V′O2. For example, a 1 L lower FEV1 and FVC was associated with a 7.1% (95% CI 5.1–9.1%) and 6.0% (95% CI 4.3–7.7%) lower peak V′O2, respectively. By contrast, FEV1/FVC was not associated with peak V′O2. Lower lung function was associated with lower oxygen uptake efficiency slope, oxygen pulse slope, V′O2 at anaerobic threshold (AT), minute ventilation (V′E) at AT and breathing reserve. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak V′O2.Conclusions In a large, community-based cohort of adults, we found lower FEV1, FVC and DLCO were associated with lower exercise capacity, as well as oxygen uptake efficiency slope and ventilatory efficiency. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak V′O2. These findings underscore the importance of lung function and blood vessel volume as contributors to overall exercise capacity.Lower FEV1, FVC and DLCO were associated with lower exercise capacity, as well as oxygen uptake efficiency slope and ventilatory efficiency. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak V′O2. https://bit.ly/31VVpsu ER -