RT Journal Article
SR Electronic
T1 Relationship between glucosamine use and the risk of lung cancer: data from a nationwide prospective cohort study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2101399
DO 10.1183/13993003.01399-2021
VO 59
IS 3
A1 Guowei Li
A1 Xuhui Zhang
A1 Yingxin Liu
A1 Junguo Zhang
A1 Likang Li
A1 Xin Huang
A1 Lehana Thabane
A1 Gregory Y.H. Lip
YR 2022
UL http://erj.ersjournals.com/content/59/3/2101399.abstract
AB Background Research on glucosamine shows anti-inflammatory and anti-cancer benefits with minimal adverse effects. We aimed to explore the relationship between use of glucosamine and risk of lung cancer and lung cancer mortality based on data from the large-scale nationwide prospective UK Biobank cohort study.Methods Participants were enrolled between 2006 and 2010 and followed-up to 2020. The Cox proportional hazards model was used to assess the relationship between glucosamine use and risk of lung cancer and lung cancer mortality. Subgroup analyses and sensitivity analyses were performed to explore the potential effect modifications and the robustness of the main findings.Results 439 393 participants (mean age 56 years; 53% females) with a mean follow-up of 11 years were included for analyses. 82 603 (18.80%) participants reported regular use of glucosamine at baseline. During follow-up, 1971 (0.45%) lung cancer events were documented. Glucosamine use was significantly associated with a decreased risk of lung cancer (hazard ratio (HR) 0.84, 95% CI 0.75–0.92; p<0.001) and lung cancer mortality (HR 0.88, 95% CI 0.81–0.96; p=0.002) in fully adjusted models. A stronger association between glucosamine use and decreased lung cancer risk was observed in participants with a family history of lung cancer when compared with those without a family history.Conclusion Regular use of glucosamine was significantly related with decreased risk of lung cancer and lung cancer mortality, based on data from this nationwide prospective cohort study.Regular use of glucosamine was significantly related with a 16% lower risk of lung cancer and a 12% decreased risk of lung cancer mortality https://bit.ly/3ixJAND