TY - JOUR T1 - Reply: Measurement of hypoxia in the lung in idiopathic pulmonary fibrosis: a matter of control JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.03124-2021 VL - 59 IS - 3 SP - 2103124 AU - Joanna C. Porter AU - Thida Win AU - Kjell Erlandsson AU - Kris Thielemans AU - Ashley M. Groves Y1 - 2022/03/01 UR - http://erj.ersjournals.com/content/59/3/2103124.abstract N2 - We thank P-S. Bellaye and co-workers for their considered and insightful response. Given their finding of [18F]fluoromisonidazole ([18F]F-MISO) uptake in the bleomycin mouse model of fibrosis [1], we too were surprised not to demonstrate a similar signal in patients with idiopathic pulmonary fibrosis (IPF). However, as acknowledged, there are other examples of positron emission tomography (PET) tracers, such as cis-4-[18F]-fluoro-l-proline, yielding PET signals in animal lung fibrosis models that have not been replicated in humans with fibrotic lung disease [2, 3].In vivo PET imaging in IPF patients shows no significant evidence of lung tissue hypoxia https://bit.ly/3fywY7K ER -