PT  - JOURNAL ARTICLE
AU  - Ismail M. Osmanov
AU  - Ekaterina Spiridonova
AU  - Polina Bobkova
AU  - Aysylu Gamirova
AU  - Anastasia Shikhaleva
AU  - Margarita Andreeva
AU  - Oleg Blyuss
AU  - Yasmin El-Taravi
AU  - Audrey DunnGalvin
AU  - Pasquale Comberiati
AU  - Diego G. Peroni
AU  - Christian Apfelbacher
AU  - Jon Genuneit
AU  - Lyudmila Mazankova
AU  - Alexandra Miroshina
AU  - Evgeniya Chistyakova
AU  - Elmira Samitova
AU  - Svetlana Borzakova
AU  - Elena Bondarenko
AU  - Anatoliy A. Korsunskiy
AU  - Irina Konova
AU  - Sarah Wulf Hanson
AU  - Gail Carson
AU  - Louise Sigfrid
AU  - Janet T. Scott
AU  - Matthew Greenhawt
AU  - Elizabeth A. Whittaker
AU  - Elena Garralda
AU  - Olivia V. Swann
AU  - Danilo Buonsenso
AU  - Dasha E. Nicholls
AU  - Frances Simpson
AU  - Christina Jones
AU  - Malcolm G. Semple
AU  - John O. Warner
AU  - Theo Vos
AU  - Piero Olliaro
AU  - Daniel Munblit
ED  - ,
TI  - Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study
AID  - 10.1183/13993003.01341-2021
DP  - 2022 Feb 01
TA  - European Respiratory Journal
PG  - 2101341
VI  - 59
IP  - 2
4099  - http://erj.ersjournals.com/content/59/2/2101341.short
4100  - http://erj.ersjournals.com/content/59/2/2101341.full
SO  - Eur Respir J2022 Feb 01; 59
AB  - Background The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors.Methods This is a prospective cohort study of children (≤18 years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5 months) were further categorised by system(s) involved.Results 518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3–15.2) years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (OR 2.74, 95% CI 1.37–5.75) and “12–18 years” (OR 2.68, 95% CI 1.41–5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04–2.67).Conclusions A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.A quarter of children experienced persistent symptoms months after COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up. https://bit.ly/3vqeEmZ