TY - JOUR T1 - The discovAIR project: a roadmap towards the Human Lung Cell Atlas JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02057-2021 SP - 2102057 AU - Malte D. Luecken AU - Laure-Emmanuelle Zaragosi AU - Elo Madissoon AU - Lisa Sikkema AU - Alexandra B. Firsova AU - Elena De Domenico AU - Louis Kümmerle AU - Adem Saglam AU - Marijn Berg AU - Aurore C.A. Gay AU - Janine Schniering AU - Christoph H. Mayr AU - Xesús M. Abalo AU - Ludvig Larsson AU - Alexandros Sountoulidis AU - Sarah Teichmann AU - Karen van Eunen AU - Gerard H. Koppelman AU - Kourosh Saeb-Parsy AU - Sylvie Leroy AU - Pippa Powell AU - Ugis Sarkans AU - Wim Timens AU - Joakim Lundeberg AU - Maarten van den Berge AU - Mats Nilsson AU - Peter Horváth AU - Jessica Denning AU - Irene Papatheodorou AU - Joachim Schultze AU - Herbert B. Schiller AU - Pascal Barbry AU - Ilya Petoukhov AU - Alexander V. Misharin AU - Ian Adcock AU - Michael von Papen AU - Fabian J. Theis AU - Christos Samakovlis AU - Kerstin B. Meyer AU - Martijn C. Nawijn Y1 - 2022/01/01 UR - http://erj.ersjournals.com/content/early/2022/01/27/13993003.02057-2021.abstract N2 - The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The lung biological network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and the cell–cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework program. DiscovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Malte D. Luecken has nothing to disclose.Conflict of interest: Laure-Emmanuelle Zaragosi has nothing to disclose.Conflict of interest: Elo Madissoon has nothing to disclose.Conflict of interest: Lisa Sikkema has nothing to disclose.Conflict of interest: Alexandra B. Firsova has nothing to disclose.Conflict of interest: Elena De Domenico has nothing to disclose.Conflict of interest: Louis Kümmerle has nothing to disclose.Conflict of interest: Adem Saglam has nothing to disclose.Conflict of interest: Marijn Berg has nothing to disclose.Conflict of interest: Aurore C.A. Gay has nothing to disclose.Conflict of interest: Janine Schniering has nothing to disclose.Conflict of interest: Christoph H. Mayr has nothing to disclose.Conflict of interest: Xesús M. Abalo has nothing to disclose.Conflict of interest: Ludvig Larsson has nothing to disclose.Conflict of interest: Alexandros Sountoulidis has nothing to disclose.Conflict of interest: Sarah Teichmann has nothing to disclose.Conflict of interest: Karen van Eunen has nothing to disclose.Conflict of interest: Dr. Koppelman reports grants from Lung Foundation of the Netherlands, GSK, Vertex, TEVA the Netherlands, UBBO EMMIUS Foundation, European Union (H2020 grant), outside the submitted work and he has participated in advisory board meetings to GSK and PURE-IMS, outside the submitted work.Conflict of interest: Kourosh Saeb-Parsy has nothing to disclose.Conflict of interest: Sylvie Leroy has nothing to disclose.Conflict of interest: P. Powell is employees of the European Lung Foundation.Conflict of interest: Ugis Sarkans has nothing to disclose.Conflict of interest: Dr. Timens reports personal fees from Merck Sharp Dohme, personal fees from Bristol-Myers-Squibb, outside the submitted work.Conflict of interest: Dr. Lundeberg reports personal fees from 10x Genomics Inc, outside the submitted work.Conflict of interest: Dr. van den Berge reports research grants paid to UMCG from GlaxoSmithKline, Genentech, Roche, Novartis, outside the submitted work.Conflict of interest: Dr. Nilsson reports personal fees from 10x Genomics, outside the submitted work.Conflict of interest: Peter Horváth has nothing to disclose.Conflict of interest: J. Denning is employees of the European Lung Foundation.Conflict of interest: Irene Papatheodorou has nothing to disclose.Conflict of interest: Joachim Schultze has nothing to disclose.Conflict of interest: Herbert B. Schiller has nothing to disclose.Conflict of interest: Pascal Barbry has nothing to disclose.Conflict of interest: Ilya Petoukhov has nothing to disclose.Conflict of interest: Alexander V. Misharin has nothing to disclose.Conflict of interest: Ian Adcock has nothing to disclose.Conflict of interest: Michael von Papen has nothing to disclose.Conflict of interest: Dr. Theis reports personal fees and non-financial support from Cellarity, and from Dermagnostix, during the conduct of the study; Janine Schniering was supported by a ERS/EU RESPIRE4 Marie Sklodowska Curie Postdoctoral Fellowship.Conflict of interest: Christos Samakovlis has nothing to disclose.Conflict of interest: Kerstin B. Meyer has nothing to disclose.Conflict of interest: Dr. Nawijn reports grants from European Commission, grants from Chan Zuckerberg Initiative, and grants from The Netherlands Lung Foundation, during the conduct of the study; grants from GSK Ltd, outside the submitted work. ER -