TY - JOUR T1 - A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02603-2021 VL - 59 IS - 1 SP - 2102603 AU - Mahmoud I. Abdel-Aziz AU - Susanne J.H. Vijverberg AU - Anne H. Neerincx AU - Paul Brinkman AU - Ariane H. Wagener AU - John H. Riley AU - Ana R. Sousa AU - Stewart Bates AU - Scott S. Wagers AU - Bertrand De Meulder AU - Charles Auffray AU - Åsa M. Wheelock AU - Aruna T. Bansal AU - Massimo Caruso AU - Pascal Chanez AU - Mohib Uddin AU - Julie Corfield AU - Ildiko Horvath AU - Norbert Krug AU - Jacek Musial AU - Kai Sun AU - Dominick E. Shaw AU - Thomas Sandström AU - Paolo Montuschi AU - Stephen J. Fowler AU - René Lutter AU - Ratko Djukanovic AU - Peter Howarth AU - Paul Skipp AU - Marek Sanak AU - Ian M. Adcock AU - Kian Fan Chung AU - Peter J. Sterk AU - Aletta D. Kraneveld AU - Anke H. Maitland-van der Zee A2 - , Y1 - 2022/01/01 UR - http://erj.ersjournals.com/content/59/1/2102603.abstract N2 - Asthma is a heterogeneous disease with multiple clinical presentations (phenotypes) [1]. Neutrophilic asthma is characterised by increased sputum neutrophils and generally has a poor response to corticosteroids and limited other therapeutic options. Neutrophilia originates from different factors, including the defective resolution of inflammation or bacterial infections [2]. An association between airway bacterial imbalance (disturbance) and the neutrophilic phenotype has been reported [3], suggesting that airway microbiota composition is involved in neutrophilic asthma. Rather than being a separate entity [4], neutrophilic asthma may be in part, an alliance between innate immunity and microbiota composition that prompts protective mechanisms against invading pathogens [2].A multi-omics approach revealed the underlying biological pathways in the microbiome-driven severe asthma phenotypes. This may help to elucidate new leads for treatment development, particularly for the therapeutically challenging neutrophilic asthma. https://bit.ly/3FWuJqS ER -