TY - JOUR T1 - The prognostic role of matrix metalloproteinase-7 in scleroderma-associated interstitial lung disease JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01560-2021 VL - 58 IS - 6 SP - 2101560 AU - Scott M. Matson AU - Seoyeon J. Lee AU - Ryan A. Peterson AU - Natalia A. Achtar-Zadeh AU - Francesco Boin AU - Paul J. Wolters AU - Joyce S. Lee Y1 - 2021/12/01 UR - http://erj.ersjournals.com/content/58/6/2101560.abstract N2 - Systemic sclerosis (SSc) has the highest mortality rate amongst rheumatologic diseases [1]. It is characterised by endothelial dysfunction resulting in a small vessel vasculopathy leading to inflammation and fibrosis of skin and internal organs, including the lungs [1]. Pulmonary manifestations of SSc (pulmonary hypertension and interstitial lung disease (ILD)) account for the majority of deaths in these patients, and ILD alone accounts for a third of the mortality observed in SSc patients [2].Matrix metalloproteinase-7 level is associated with worse baseline pulmonary function and worse transplant-free survival in scleroderma interstitial lung disease https://bit.ly/3zZhja7 ER -