RT Journal Article
SR Electronic
T1 Serum levels of small HDL particles are negatively correlated with death or lung transplantation in an observational study of idiopathic pulmonary fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2004053
DO 10.1183/13993003.04053-2020
VO 58
IS 6
A1 Amisha V. Barochia
A1 Maryann Kaler
A1 Nargues Weir
A1 Elizabeth M. Gordon
A1 Debbie M. Figueroa
A1 Xianglan Yao
A1 Merte Lemma WoldeHanna
A1 Maureen Sampson
A1 Alan T. Remaley
A1 Geraldine Grant
A1 Scott D. Barnett
A1 Steven D. Nathan
A1 Stewart J. Levine
YR 2021
UL http://erj.ersjournals.com/content/58/6/2004053.abstract
AB Background Serum lipoproteins, such as high-density lipoproteins (HDL), may influence disease severity in idiopathic pulmonary fibrosis (IPF). Here, we investigated associations between serum lipids and lipoproteins and clinical end-points in IPF.Methods Clinical data and serum lipids were analysed from a discovery cohort (59 IPF subjects, 56 healthy volunteers) and validated using an independent, multicentre cohort (207 IPF subjects) from the Pulmonary Fibrosis Foundation registry. Associations between lipids and clinical end-points (forced vital capacity, 6-min walk distance, gender age physiology (GAP) index, death or lung transplantation) were examined using Pearson's correlation and multivariable analyses.Results Serum concentrations of small HDL particles measured using nuclear magnetic resonance spectroscopy (S-HDLPNMR) correlated negatively with the GAP index in the discovery cohort of IPF subjects. The negative correlation of S-HDLPNMR with GAP index was confirmed in the validation cohort of IPF subjects. Higher levels of S-HDLPNMR were associated with lower odds of death or its competing outcome, lung transplantation (OR 0.9 for each 1-μmol·L−1 increase in S-HDLPNMR, p<0.05), at 1, 2 and 3 years from study entry in a combined cohort of all IPF subjects.Conclusions Higher serum levels of S-HDLPNMR are negatively correlated with the GAP index, as well as with lower observed mortality or lung transplantation in IPF subjects. These findings support the hypothesis that S-HDLPNMR may modify mortality risk in patients with IPF.This is the first study showing that higher serum levels of small HDL particles correlate with a lower risk of death or lung transplantation in patients with idiopathic pulmonary fibrosis, suggesting that they may be important in IPF pathobiology https://bit.ly/2RG4UGS