RT Journal Article
SR Electronic
T1 Tissue lesions in rat lungs caused by Crotalus durissus collilineatus venom
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3615
DO 10.1183/13993003.congress-2021.PA3615
VO 58
IS suppl 65
A1 Afonso, João Pedro
A1 Franco De Oliveira, Luis Vicente
A1 Mota Da Silva, Marcos
A1 Alves Costa, Isabella
A1 Moreira Lino, Maria Eduarda
A1 Da Silva Junior, Leandro Norberto
A1 De Paula Vieira, Rodolfo
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3615.abstract
AB Tissue lesions in rat lungs caused by Crotalus durissus collilineatus venom In 2009, the World Health Organization (WHO) in the list of Neglected Tropical Diseases included snakebite. In most cases, these accidents affect low-income populations living in rural areas, with little or no access to health services. Specimens of the subfamily Crotalinae constitute a group of species that have a wide geographical distribution, occurring in the regions of the Americas and Eurasia. Snakes of this genus have habitats all over Brazil and are responsible for about 8% of the ophidic accidents, reaching a lethality rate of 1.7% (Mcdiarmid, 1999; Bertolozzi, 2015). Due to these data, it is important to understand better the action of the poison in the organism so that it can develop better treatment protocols for this disease. This study investigated lung histology in an experimental model of acute lung injury induced by the effects of Crotalus durissus collilineatus (Cdc) venom on the lungs of male Wistar rats. The animals were divided into four groups and the crude poison, as well as the control, were inoculated intramuscularly into the cranial musculature of the right pelvic limb, with the C (Control) being inoculated with 1µL / g of 0.9% isotonic saline, while in groups V30 '(Poison 30 Minutes), V2 (Poison 2 Hours) and V3 (Poison 3 Hours) the lethal dose of 1µg / g of body weight was injected. After collecting the organs, histological analysis of the lungs was performed, being possible to observe the presence of vascular dilation, hemorrhagic thrombi, and xanthomized macrophages in alveoli. Such results demonstrate that the crude Cdc poison induced histopathological changes in the studied lungs.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3615.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).