RT Journal Article SR Electronic T1 Late Breaking Abstract - The role of High Flow Nasal Cannula in reducing hypoxemic events during bronchoscopic procedures compared to Low Flow Nasal Cannula: a metanalysis JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA3801 DO 10.1183/13993003.congress-2021.PA3801 VO 58 IS suppl 65 A1 Fotios Sampsonas A1 Vasilios Karamouzos A1 Theodoros Karampitsakos A1 Ournia Papaioannou A1 Matthaios Katsaras A1 Maria Lagadinou A1 Dimitrios Velissaris A1 Grigorios Stratakos A1 Argyrios Tzouvelekis YR 2021 UL http://erj.ersjournals.com/content/58/suppl_65/PA3801.abstract AB High Flow Nasal Cannula oxygenation method is effective in oxygenation of patients with respiratory failure and has shown clinical benefits over Low Flow Nasal Cannula. We performed a metanalysis to evaluate the potential favorable impact of the High Flow Nasal Cannula oxygenation during bronchoscopy and related procedures like EBUS-TBNA. Eight studies with 488 patients have been included in this metanalysis, after screening a bulk of 144 studies.All these studies met quality criteria as defined by ROB-2 tool l to evaluate the risk of bias in the included randomized controlled studies and ROBINS-I tool for non-randomized studies.Patients that underwent bronchoscopy (EBUS and/or Fiberoptic bronchoscopy) with the use of High Flow Nasal Cannula experienced less hypoxemic events/desaturations compared to patients under Low Flow Nasal Cannula treatment (O.R.= 0.24; 95% CI= 0.16,0.37; p<0.01; I2= 71%).Desaturation events were lower using HFNC whether FOB +/-BAL or Biopsy was performed (O.R.=0.36; 95% CI= 0.2,0.65; p<0.01; I2 = 83%) or EBUS-TBNA (O.R.=0.15; 95% CI= 0.08,0.30; p<0.01; I2 = 0%). This abstract shows that that High Flow Nasal Cannula oxygen therapy might more effective compared to Low Flow Nasal Cannula therapy in reducing hypoxemic events during bronchoscopy, especially during EBUS-TBNA.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3801.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).