TY - JOUR T1 - Late Breaking Abstract - The role of High Flow Nasal Cannula in reducing hypoxemic events during bronchoscopic procedures compared to Low Flow Nasal Cannula: a metanalysis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2021.PA3801 VL - 58 IS - suppl 65 SP - PA3801 AU - Fotios Sampsonas AU - Vasilios Karamouzos AU - Theodoros Karampitsakos AU - Ournia Papaioannou AU - Matthaios Katsaras AU - Maria Lagadinou AU - Dimitrios Velissaris AU - Grigorios Stratakos AU - Argyrios Tzouvelekis Y1 - 2021/09/05 UR - http://erj.ersjournals.com/content/58/suppl_65/PA3801.abstract N2 - High Flow Nasal Cannula oxygenation method is effective in oxygenation of patients with respiratory failure and has shown clinical benefits over Low Flow Nasal Cannula. We performed a metanalysis to evaluate the potential favorable impact of the High Flow Nasal Cannula oxygenation during bronchoscopy and related procedures like EBUS-TBNA. Eight studies with 488 patients have been included in this metanalysis, after screening a bulk of 144 studies.All these studies met quality criteria as defined by ROB-2 tool l to evaluate the risk of bias in the included randomized controlled studies and ROBINS-I tool for non-randomized studies.Patients that underwent bronchoscopy (EBUS and/or Fiberoptic bronchoscopy) with the use of High Flow Nasal Cannula experienced less hypoxemic events/desaturations compared to patients under Low Flow Nasal Cannula treatment (O.R.= 0.24; 95% CI= 0.16,0.37; p<0.01; I2= 71%).Desaturation events were lower using HFNC whether FOB +/-BAL or Biopsy was performed (O.R.=0.36; 95% CI= 0.2,0.65; p<0.01; I2 = 83%) or EBUS-TBNA (O.R.=0.15; 95% CI= 0.08,0.30; p<0.01; I2 = 0%). This abstract shows that that High Flow Nasal Cannula oxygen therapy might more effective compared to Low Flow Nasal Cannula therapy in reducing hypoxemic events during bronchoscopy, especially during EBUS-TBNA.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3801.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -