RT Journal Article SR Electronic T1 A data management and analysis platform for RASP-UK multiomics clinical datasets JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP OA4058 DO 10.1183/13993003.congress-2021.OA4058 VO 58 IS suppl 65 A1 Zounemat Kermani, nazanin A1 Busby, John A1 Sun, Kai A1 Pandis, Ioannis A1 Gainsborough, Gabrielle A1 Guo, Yike A1 Adcock, Ian A1 Hardman, Tim A1 Heaney, Liam YR 2021 UL http://erj.ersjournals.com/content/58/suppl_65/OA4058.abstract AB Background: United Kingdom Refractory Asthma Stratification Programme (RASP-UK) is a randomised trial of corticosteroid optimisation in severe asthma based on composite biomarkers [1]. TranSMART is an open-source data warehouse and analysis platform developed to store large amounts of clinical and omics data[2]. Using a data management platform ensures: accessibility, sustainability and transparency of data which is essential for future respiratory projects within the EU.Aim: Our aim was to deploy a tranSMART platform and to apply the extract-transform-load (ETL) process for RASP-UK datasets and with a 100% accuracy.Methods: TranSMART were deployed on the Data Science Institute (DSI) servers (https://rasp.dsi.ic.ac.uk/transmart/). After the ETL process data was uploaded to the tranSMART platform (Fig 1-A, C). The accuracy of the ETL process was confirmed by a full recompile of the study dataset from TranSMART and a field-by-field comparison with the index data (Fig 1-B).Fig1-A is a screenshot of the platform. B shows the ETL and the testing process. C shows a summary of the data.Results: A tranSMART platform were deployed and RASP-UK datasets were uploaded to the platform with a 100% accuracy.Conclusions: TranSMART platform contributes to the accessibility and sustainability of large data-centred projects.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA4058.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).